{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"100-825-752-514-146","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"100-825-752-514-146"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11624,"type":"PATENT","title":"Mayo Medical School - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":5667,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8299,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: mayo medi*
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Select all patents in the collection and expand by simple families. Add to collection. Total patents: 5671
Search Applicants and Owners separately: mayo medi*
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Select all patents in the collection and expand by simple families. Add to collection. Total patents: 5671
(a) determining the methylation status in a RUNX3 nucleic acid and a COX-2 nucleic acid in said human,\n
(b) classifying said mammal as having or as having an increased risk of developing said colorectal cancer if said RUNX3 nucleic acid methylation status is elevated and said COX-2 nucleic acid methylation status is reduced as compared to a normal control, and\n
(c) classifying said mammal as not having or as not having at an increased risk of developing said colorectal cancer if said RUNX3 nucleic acid methylation status is not elevated and said COX-2 nucleic acid methylation status is not reduced."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein said inflammatory bowel disease is histologically inactive."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, further comprising determining the level of an MPO polypeptide in said mammal, wherein an elevated level of said MPO polypeptide is indicative of the presence of or an increased risk of developing colorectal cancer."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, further comprising determining the methylation status of a MINT1 nucleic acid in said mammal, wherein an elevated level of said MINT1 nucleic acid methylation status is indicative of the presence of or an increased risk of developing said colorectal cancer."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, further comprising determining whether or not said mammal contains a polymorphism in a nucleic acid encoding a TNF-alpha protein, wherein the presence of said polymorphism is associated with the presence of or an increased risk of said colorectal cancer."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein said polymorphism is rs1800629."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A method for assessing a biopsy sample from an ulcerative colitis patient having the presence of a polymorphism in a TNF-alpha nucleic acid, said method comprising analyzing said biopsy sample for at least two markers selected from the group consisting of an MPO polypeptide level, methylation status of a RUNX3 nucleic acid, methylation status of a MINT1 nucleic acid, and methylation status of a COX-2 nucleic acid."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["A method for assessing a mammal diagnosed with inflammatory bowel disease for the presence of or an increased risk of developing colorectal cancer, wherein said method comprises:\n
(a) detecting the presence of at least two markers in said mammal, wherein said at least two markers are selected from the group consisting of elevated MPO polypeptide levels, elevated RUNX3 methylation status, elevated MINT1 methylation status, and reduced COX-2 methylation status, and\n
(b) classifying said mammal as having colorectal cancer or as being at an increased risk of developing colorectal cancer based at least in part on said presence of said at least two markers."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["A method for assessing a mammal with histologically inactive inflammatory bowel disease for the presence of colorectal cancer or an increased risk of developing colorectal cancer, where said method comprises:\n
(a) detecting the presence of at least two markers in said mammal, wherein said at least two markers are selected from a group consisting of the presence of at least one polymorphism in a TNF alpha nucleic acid, an elevated MPO polypeptide level, an elevated methylation level of a RUNX3 nucleic acid, an elevated methylation level of a MINT1 nucleic acid, and a reduced methylation level of a COX-2 nucleic acid, and\n
(b) classifying said mammal as having colorectal cancer or as being at an increased risk of developing colorectal cancer based at least in part on said presence of said at least two markers."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["A method for assessing a mammal diagnosed with inflammatory bowel disease for the presence of or an increased risk of developing colorectal cancer, wherein said method comprises:\n
(a) detecting the presence of an elevated level of RUNX3 nucleic acid methylation and a reduced level of COX-2 nucleic acid methylation in said mammal, and\n
(b) classifying said mammal as having or as having an increased risk of developing said colorectal cancer based at least in part on said presence."],"number":18,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}