Terminal differentiation is associated with repression in the expression of the P2P subset of hnRNP proteins. The present invention provides a P2P cDNA that encodes proteins with domains for hnRNP association and Rb1 binding. Probes to the P2P cDNA detect a single 8 kb mRNA in multiple murine tissues, in proliferating murine 3T3 cells but not in terminally differentiated 3T3T adipocytes. The interaction of P2P cDNA products and Rb1 may serve to modulate cell proliferation and/or other biological functions associated with tumor suppression by an RNA processing mechanism. Moreover, it was shown that P2P antisense oligonucleotides selectively repressed 30-40 kDa P2P expression.

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Document History
  • Publication: Apr 9, 2002
  • Application: Feb 18, 1997
    US US 80130897 A
  • Priority: Feb 18, 1997
    US US 80130897 A
  • Priority: Sep 27, 1996
    US US 2756896 P

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