Method For Manufacturing A Recombinant Polyclonal Protein

Abstract

The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one member of the collection, which encodes a distinct member of a polyclonal protein. The cells are cultured under suitable conditions for expression of the polyclonal protein, which is obtained from the cells or culture supernatant. The nucleic acid sequence is introduced into the cells by transfection with a collection of vectors. The present method is suitable for manufacturing recombinant polyclonal antibodies for therapeutic uses.


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Document History
  • Publication: Mar 22, 2011
  • Application: May 23, 2008
    US US 15380908 A
  • Priority: May 23, 2008
    US US 15380908 A
  • Priority: Sep 11, 2007
    US US 96000207 P
  • Priority: Sep 7, 2007
    DK DK PA200701292 A
  • Priority: May 29, 2007
    US US 92470807 P
  • Priority: May 25, 2007
    DK DK PA200700764 A

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