A Radiomics-based Imaging Tool To Monitor Tumor-lymphocyte Infiltration And Outcome In Cancer Patients Treated By Anti-pd-1/pd-l1

  • Published: Jan 17, 2019
  • Earliest Priority: Jun 01 2018
  • Family: 1
  • Cited Works: 68
  • Cited by: 0
  • Cites: 2
  • Additional Info: Cited Works Full text
Abstract

The present invention proposes a radiomics-based biomarker for detecting the presence and the density of tumor infiltrating CD8 T-cells in a solid tumor without having to use any biopsy of said tumor. The invention also proposes to use this information to assess the immune phenotype of said solid tumor. In a particular embodiment, the invention proposes to prognose the survival and / or the treatment efficiency of cancer patients treated with immunotherapy such as anti-PD-1/PD- L1 monotherapy.


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Document History
  • Publication: Jan 17, 2019
  • Application: Jul 13, 2018
    WO EP 2018069169 W
  • Priority: Jun 1, 2018
    EP EP 18305680 A
  • Priority: Jul 13, 2017
    US US 201762532139 P

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