{"search_session":{},"preferences":{"l":"ar","queryLanguage":"ar"},"patentId":"097-609-276-545-933","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"097-609-276-545-933","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11789,"type":"PATENT","title":"Newcastle University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":9350,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8422,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: Newcastle Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1333
Search Applicants and Owners separately: Newcastle Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1333
(a) obtaining a blood sample from the subject; and\n
(b) detecting risk for Chagas disease related cardiomyopathy by\n"],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein protein levels are determined by image analysis of two-dimensional gels."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the level of cysteinyl-S-nitrosylation (SNO) is measured by saturation fluorescence labeling."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["A method of treating a patient at risk of chagasic cardiomyopathy comprising:\n(i) measuring protein levels and cysteinyl-S-nitrosylation (SNO) levels of actin (cytoplasmic isoforms 1 or 2), keratin type II, POTE Ankyrin domain family member E, Ras-related protein Rap1B, serum albumin, or SH3 domain binding glutamic acid-rich-like protein 3 in the blood sample from the subject and\n(ii) calculating a ratio of an SNO ratio to a protein abundance ratio for the proteins, wherein (1) the SNO ratio is the SNO level in the sample over the SNO level in a control and (2) protein abundance ratio is the abundance of the proteins detected after treatment of the sample to remove SNO groups over the protein level in a control after treatment of the control to remove SNO groups,\nwherein the ratio of an SNO ratio to a protein abundance ratio for the proteins is an indicator of Chagas disease related cardiomyopathy.\n
administering a treatment for cardiomyopathy to a patient identified as being at risk for Chagas disease related cardiomyopathy using the method of claim 1."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 4, wherein the patient is an asymptomatic patient."],"number":5,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}