{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"095-471-977-847-684","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"095-471-977-847-684"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11646,"type":"PATENT","title":"UT M. D. Anderson Cancer Center - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4091,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8312,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:anderson cancer texas
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Add to collection. Total patents: 4097
Search Applicants and Owners separately:anderson cancer texas
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Add to collection. Total patents: 4097
a) obtaining a cell expressing a TLR-4 polypeptide, wherein the TLR-4 polypeptide has the amino acid sequence of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:98 or SEQ ID NO:99, or is encoded by a nucleic acid sequence comprising SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:46, SEQ ID NO:47 or SEQ ID NO:48;\n
b) measuring a lipopolysaccharide mediated response mediated by the TLR-4 polypeptide;\n
c) contacting the TLR-4 polypeptide with a putative modulator;\n
d) assaying for a change in the lipopolysaccharide mediated response; and\n
e) comparing the lipopolysaccharide mediated responses mediated by the TLR-4 polypeptide obtained in steps b) and d) above\nwherein a difference in the lipopolysaccharide mediated responses indicates that the putative modulator is a modulator of a lipopolysaccharide mediated response."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the lipopolysaccharide mediated response mediated by the TLR-4 polypeptide is determined by determining the ability of the TLR-4 polypeptide to stimulate transcription of a reporter gene, the reporter gene operatively positioned under control of a nucleic acid segment comprising a promoter from a TLR-4 gene."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the TLR-4 polypeptide has the amino acid sequence of SEQ ID NO:2."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the TLR-4 polypeptide has the amino acid sequence of SEQ ID NO:4."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the TLR-4 polypeptide has the amino acid sequence of SEQ ID NO:6."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the TLR-4 polypeptide has the amino acid sequence of SEQ ID NO:98."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the TLR-4 polypeptide has the amino acid sequence of SEQ ID NO:99."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said putative modulator is effective in altering the mediation of the lipopolysacharide mediated response by TLR-4."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein said putative modulator is an agonist of the lipopolysaccharide mediated response."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein said putative modulator is an antagonist of the lipopolysaccharide mediated response."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein said putative modulator affects the transcription of TLR-4."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein said putative modulator affects the translation of TLR-4."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said putative modulator inhibits TLR-4 directed signaling of TNF secretion."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said putative modulator stimulates TLR-4 directed signaling of TNF secretion."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said putative modulator to be screened is obtained from a library of synthetic chemicals."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said putative modulator to be screened is obtained from a natural source."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16, wherein said natural source is selected from the group consisting of animals, bacteria, fungi, plant sources, and living marine samples."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said putative modulator to be screened is a protein or peptide."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said putative modulator to be screened is a nucleic acid molecule."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said putative modulator to be screened is a stimulator of an immune response."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 20, wherein said stimulator of an immune response is a cytokine."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 20, wherein said stimulator of an immune response is an interferon."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said putative modulator to be screened is an IL-1 receptor antagonist."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said putative modulator to be screened is a small molecule."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 24, wherein said small molecule inhibits TLR-4 mediation of the lipopolysaccharide mediated response."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 24, wherein said small molecule inhibits the lipopolysaccharide mediated response."],"number":26,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}