{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"094-882-110-662-222","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"094-882-110-662-222"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":6802,"type":"PATENT","title":"Univ Queensland Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8841,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8194,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Copied from Raj's collection ' Univ Queensland'
.......................
Annie's search
Search applicants = 'Univ* AND Queensl* AND NOT Technology', 'Univ* AND Queensl* AND NOT STATE', ' Univ* AND Queensl* AND NOT STATE AND NOT TECHNOLOGY'.
notes: When search ' Univ* AND Queens* AND NOT Technology' only, the results came out with many patents that belong to Queensland State Government and Other universities. Hence, re set the search terms as' ' Univ* AND Queensl* AND NOT STATE AND NOT TECHNOLOGY'.
Search Owners(US) = ' Univ* AND Queensl* AND NOT STATE AND NOT TECHNOLOGY'
Add to collection
Select more for logical variants
Select all the patents in the collection and expand by simple families
Add to collection
Total patents = 8993
Search Applicants and Owners separately: \"Univ* Queensland\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4376
\n","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3943,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2016-06-13T09:23:24Z","updated":"2017-08-08T02:15:44Z","lastEventDate":"2017-08-08T02:15:44Z"},{"id":22745,"type":"PATENT","title":"Citing Washington Univ St Louis publications","description":"Patent documents citing scholarly work of Washington Univ St Louis","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":53436,"tags":[],"user":{"id":233682368,"username":"tech","firstName":"The Lens","lastName":"Team","created":"2017-08-06T20:11:49.000Z","displayName":"The Lens 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vesicles","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":50000,"tags":[],"user":{"id":406081165,"username":"Alhrim","firstName":"","lastName":"","created":"2021-05-28T16:07:12.000Z","displayName":"Alhrim","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":true,"savedQueries":[],"created":"2021-07-16T11:41:39Z","updated":"2021-07-16T11:42:06Z","lastEventDate":"2021-07-16T11:42:06Z"},{"id":204920,"type":"PATENT","title":"CAR","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":50000,"tags":[],"user":{"id":476754895,"username":"Theresa01","firstName":"","lastName":"","created":"2022-10-30T09:22:28.000Z","displayName":"Theresa01","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2022-10-30T09:29:58Z","updated":"2022-10-30T09:30:07Z","lastEventDate":"2022-10-30T09:30:07Z"},{"id":207781,"type":"PATENT","title":"Queensland Agent","description":"Collection of Patents filled by agents who have Queensland as address","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7492,"tags":[],"user":{"id":369423973,"username":"Lens Reports","firstName":"Lens","lastName":"Reports","created":"2020-09-16T23:25:18.000Z","displayName":"Lens Reports","profilePictureKey":"lens/avatar/00bf8c3d-2675-48ad-9d6e-5cf58c675620","avatar":{"id":1069,"key":"lens/avatar/00bf8c3d-2675-48ad-9d6e-5cf58c675620"},"preferences":"{\"beta\":true,\"usage\":\"public\"}","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":true,"savedQueries":[],"created":"2023-03-06T05:04:19Z","updated":"2024-03-28T02:46:08Z","lastEventDate":"2024-03-28T02:46:08Z"}],"notes":[],"inventorships":[],"privateCollections":[],"publicCollections":[{"id":6802,"type":"PATENT","title":"Univ Queensland Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8841,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8194,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"Copied from Raj's collection ' Univ Queensland'
.......................
Annie's search
Search applicants = 'Univ* AND Queensl* AND NOT Technology', 'Univ* AND Queensl* AND NOT STATE', ' Univ* AND Queensl* AND NOT STATE AND NOT TECHNOLOGY'.
notes: When search ' Univ* AND Queens* AND NOT Technology' only, the results came out with many patents that belong to Queensland State Government and Other universities. Hence, re set the search terms as' ' Univ* AND Queensl* AND NOT STATE AND NOT TECHNOLOGY'.
Search Owners(US) = ' Univ* AND Queensl* AND NOT STATE AND NOT TECHNOLOGY'
Add to collection
Select more for logical variants
Select all the patents in the collection and expand by simple families
Add to collection
Total patents = 8993
Search Applicants and Owners separately: \"Univ* Queensland\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4376
\n","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3943,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2016-06-13T09:23:24Z","updated":"2017-08-08T02:15:44Z","lastEventDate":"2017-08-08T02:15:44Z"},{"id":22745,"type":"PATENT","title":"Citing Washington Univ St Louis publications","description":"Patent documents citing scholarly work of Washington Univ St Louis","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":53436,"tags":[],"user":{"id":233682368,"username":"tech","firstName":"The Lens","lastName":"Team","created":"2017-08-06T20:11:49.000Z","displayName":"The Lens 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The nephron progenitor cells and ureteric epithelial progenitor cells may have end uses such as for kidney repair and regeneration, bioprmting of kidneys and screening compounds for nephrotoxicity.","lang":"en","source":"WIPO_FULLTEXT","data_format":"ORIGINAL"}],"fr":[{"text":"L'invention porte sur un procédé permettant de produire simultanément à la fois des cellules progénitrices de néphron et des cellules progénitrices épithéliales urétérales, comprenant les étapes consistant à mettre en contact des cellules de mésoderme intermédiaire avec : du facteur de croissance des fibroblastes (9) et/ou du facteur de croissance des fibroblastes (20) et éventuellement un ou plusieurs autres composés choisis dans le groupe constitué par : la protéine de morphogenèse de l'os 7; l'héparine; un agoniste de Wnt; l'acide rétinoïque; et un antagoniste de RA. Les concentrations en agoniste de Wnt, acide rétinoïque et/ou antagoniste de RA peuvent être réglées pour favoriser la production relative de cellules progénitrices de néphron et de cellules progénitrices épithéliales urétérales. Les cellules de mésoderme intermédiaire sont en fin de compte dérivées de cellules souches pulripotentes humaines par l'intermédiaire d'un stade de sillon primitif postérieur. Les cellules progénitrices de néphron et les cellules progénitrices épithéliales urétérales peuvent avoir des utilisations finales comme pour la réparation et la régénération de reins, la bio-impression de reins et le criblage de composés par rapport à leur néphrotoxicité.","lang":"fr","source":"WIPO_FULLTEXT","data_format":"ORIGINAL"}]},"abstract_lang":["en","fr"],"has_abstract":true,"claim":{"en":[{"text":"CLAIMS , A method of producing nephron progenitor cells and ureteric epithelial progenitor cells including the step of contacting intermediate mesoderm (IM) ceils with; fibroblast growth factor 9 (FGF9) and/or fibroblast growth factor 20 (FGF20); and optionally^ one or more selected from the group consisting of; bone morphogeny protein 7 (B .P7); heparin; a Wnt agortist; retmoic acid (RA), analog or agonist; and an RA antagonist; to thereby produce nephron progenitor cells and ureteric epithelial progenitor cells from the IM cells. , The method of Claim 1, wherein FGF9 and/or FGF 20 is at a concentration selected from the group consisting of: in the range of about 20 ng to 1 pg/roL; in the range of about 50-500 ng mL; in the range of about 100-300 ng mL; and about 200 ng/mL. , Th method of Claim 1 or Claim 2, wherein BMP 7 is present at a concentration selected from the group consisting of: in the range of about 25 to 75 ng mL; in the range of about 35 to 60 ng/mL; in the range of about 45 to 55 ng/mL; and about 50 ng mL. , The method of any preceding claim, wherein RA, analog or agonist increases the relative production of ureteric epithelial progenitor cells from the IM cells. , The method of an preceding claim, wherein RA, analog or agonist is present at a concentration selected from the group consisting of: in the range of about 10 pM to 1 μΜ; in the range of about 30 pM to 0.5 μΜ; in the range of about 50 pM to 0.2 μΜ; and about 0.1 μΜ. , The method of any preceding claim, wherein the RA antagonist increases the relative production of nephron progenitor progenitor cells from the IM cells., The method of an preceding claim, wherein the RA antagonist is present at a concentration selected from the group consisting of: in the range of about 0.50 pM to 10 μΜ; in the range of about 0.01 μΜ to 5 μΜ; in the range of about 0.1 μΜ to 5 μΜ; and about 1 μΜ. 8. The method of any preceding claim, wherein the Wnt agonist increases the relative production of nephron progenitor progenitor cells from the IM cells. 9. The method of any preceding claim, wherein the Wnt agonist is present at a concentration selected from the group consisting of: in the range of about Ο.ίμΜ to 10 μΜ; in the range of about 0,2μΜ to 5 μ.Μ; and in the range of about 1-2 μΜ. 10. The method of any preceding claim, wherein heparin is present at a concentration in th range of about 0.1 - 10 ^i.g mL. I L The method of any preceding claim, wherein the intermediate mesoderm (IM) cells are contacted with FGF9 alone or in combination with one or more of BMP?, RA, the A antagonist, the Wnt agonist, FGF20 and/or heparin for about 72-360 hrs. 12. The method of any preceding claim, wherein the nephron progenitor cells and ureteric epithelial progenitor cells are produced synchronously or simultaneously from the ΪΜ cells. 13. The method of any preceding claim, which includes contacting posterior primitive streak cells with one or more agents that facilitate differentiation of the posterior primitive streak cells into said IM cells. 14. The method of Claim 13, which includes contacting human pluripotent stem cells (hPSCs) with one or more agents that facilitate differentiation of the iiPSCs into said posterior primitive streak cells. 15. The method of Claim 1 , wherein the hPSCs are human embryonic stem cells or induced human pluripotent stem cells. ] 6. The method of any preceding claim that includes the sequential steps of: (a) contacting human pluripotent stem (hPCS) cells with one or more agents that facilitate differentiation of the hPSC cells into posterior primitive streak cells; (b) contacting posterior primitive streak cells with one or more agents that facilitate differentiatio of the posterior primitive streak ceils into IM cells; and (c) contacting IM cells with FGF9 alone, or in combination with one or more of BMP7; RA; an RA antagonist; a Wnt agonist; FGF20; and/or heparin to thereby produce nephron progenitor cells and ureteric epithelial progenitor cells from the IM cells. 17. The method of any one of Claims 13 to 16, wherein the one or more agents contacted with the posterior primitive streak cells include fibroblast growth factor 9 (FGF9) alone or in combination with FGF2 and/or FGF20. 18. The method of Claim 17, wherein FGF9-, FGF2 and/% FGF20 are at a concentration, of about 100 to 400 ng/mL. 19. The method of any one of Claims 14 to 18, wherein the one or more agents contacted with the hPSCs include ΒΜΡ4, Activin A and/or a Wnt agonist. 20. The method of Claim 19, wherein (i) BMP4 is at a concentration of about 5- 40 ng/mL; (ii) Activin A is at a concentration of about 3-40 ng/mL; and/or the Wnt agonist is at a concentration in the range of about 0.5 to 50 uM. 21. The method of Claim 16 that includes the sequential steps of; (a) contacting human pluripotent stem (hPCS) cells with a Wnt agonist, to facilitate differentiation of the hPSC cells into posterior primitive streak cells; (b) contacting the posterior primitive streak cells with FGF9, alone or together with an RA antagonist, to facilitate differentiation of the posterior primitive streak cells into IM cells; and (c) contacting the M cells FGF9 alone or in combination with one or more of BMP7; RA; an RA antagonist; a Wnt agonist; FGF20; and/or heparin to thereby produce nephron progenitor cells and ureteric epithelial progenitor cells from the IM cells. 22. The method of any preceding claim, further including the step of identifying viable nephron progenitor cells and/or ureteric epithelial progenitor cells. 23. The method of Claim 22, wherein identification of viable nephron progenitor cells and or ureteric epithelial progenitor cells includes measurement or detection of co-expression of a plurality of nucleic acids and/or proteins as markers that identify or distinguish viable nephron and/or ureteric epithelial progenitor cells. 24. isolated, enriched or purified nephron progenitor cells and/or ureteric epithelial progenitor cells produced according to the method of any one of Claims 1 to 23. 25. A meth d of producing a kidney, or kidne cells or tissues, said method including the step of differentiating the ' kidney, or the kidney cells or tissues from the isolated or purified nephron and/or ureteric epithelial progenitor cells of Claim 24, to thereby produce the kidney, or kidney cells or tissues, 26. The isolated, enriched or purified nephron progenitor cells and/or ureteric epithelial progenitor cells of Claim 24 for use in producing a kidney, or kidney cells or tissues. 27. The method of Claim 24 for (i) bioprinting or bio-engineering whole kidneys and kidney tissue for kidney transplant or treating chronic kidney disease; (ii) the rfice!lularisaiion of whole organ decellularised kidney to thereby create a reconstituted or replacement kidney; or (hi) cellular therapy of kidney diseases and conditions, 28. A method of detennimng the nephrotoxicity of one or a plurality of compounds, said method including the step of contacting the one or plurality of compounds with the isolated or purified nephron progenitor cells and/or ureteric epithelial progenitor cells of Claim 26, or kidney cells or tissues differentiated or otherwise obtained therefrom, to thereby determine whethe or not the one or plurali ty of compounds is nephrotoxic. 29. The method of Claim 28, wherein the method is performed b contacting the one or plurali ty of compounds with a renal organoid.","lang":"en","source":"WIPO_FULLTEXT","data_format":"ORIGINAL"}]},"claim_lang":["en"],"has_claim":true,"description":{"en":{"text":"TITLE RENAL PROGENITOR CELLS TECHNICAL FIELD THIS INVENTION relates to kidney development. More particularly, this invention relates io an in vitro method of producing nephron progenitor cells and ureteric duct progenitor cells ultimately from human pluripotent stem cells. BACKGROUND With the prevalence of end stage renal disease rising 8% pa globally 1 , there is an urgent need for renal regenerative strategies. The kidney is a mesodermal organ that differentiates from the intermediate mesoderm (IM) via the formation of a ureteric hud (UB) and the interaction between this hud and the adjacent IM -derived metanephrie mesenchyme (MM) 2 . The nephrons arise from a nephron progenitor population derived from the MM 3 . The IM itself is derived from, the posterior primitive streak 4 . While the developmental origin of the kidney is well understood 2 , nephron formation in the human kidney is completed before birth 5 . Hence, there is no postnatal stem cell able to replace lost nephrons. Human Pluripotent Stem cells have great potential for the generation of a cell-based treatment for kidney disease. However, the realisation of human pluripotent stem cells as a source of cells ibr clinical use and as a treatment, such as for kidney disease, has been hindered by the lack of understanding of how to produce the necessary cell types that give rise to nephrons and other structures of the kidney. SUMMARY The present inventors have successfully directed the differentiation of human pluripotential stem cells through posterior primitive streak and intermediate mesoderm (IM) under fully chemicall defined monolayer culture conditions using growth tkctors used during normal embryogenesis. This differentiation protocol results in the synchronous induction of ureteric bud (UB) and metanephrie mesenchyme (MM) that forms a self-organising structure, includin nephron formation, in vitro. Such bJESC-derived components show broad renal potential ex vivo, illustrating the potential for pluripotent stem cell-based renal regeneration. Accordingly, one aspect of the invention provides a method of producing nephron progenitor cells and ureteric epithelial progenitor cells including the step of contacting intermediate mesoderm (IM) cells with; fibroblast growth factor 9 (FGF9) and/or fibroblast growth factor 20 (FGF20); and optionally, one or more agents selected from the group consisting of; bone morphogenie protein 7 (BMP7); heparin; a Wat agonist; retino c acid ( A), analog or agonist; and an RA antagonist; to thereby produce nephron progenitor cells and ureteric epithelial progenitor cells from the IM cells, In one embodiment,, the IM cells are derived or differenti ted from posterior primitive streak cells. In one embodiment, the posterior primitive streak cells are derived or differentiated from human pluripoierit stem cells (hPSCs). Non-Mmiting examples of hPSCs include human embryonic stem cells (hESCs) and induced human pluripotent stem cells (iPSCs). In a preferred form, th s aspect provides a method that includes the sequential steps of; (i) contacting hPSCs with one or more agents that facilitate differentiation of the hPSCs into posterior primitive streak cells; (ii) contacting the posterior primiti ve streak cells with one or more agents that facilitate differentiation of the posterior primitive streak cells into IM cells; and (iii) contacting IM cells with FGF9 alone or in combination with one or more of: BMP7; RA; an RA antagonist; a Wnt agonist; and/or FGF20; and heparin; to thereby produce nephron progenitor cells and ureteric epithelial progenitor cells from the IM cells. The one or more agents at step (ii) preferably include FGF9. In one particular embodiment, FGF9 is present for at least part of, or entirely throughout, both steps (ii) and (iii). In a particularly preferred embodiment, a Wnt agonist such as CHI 99021 is present during step (i). In one embodiment, the method further includes the step of identifying viable nephron progenitor cells and/or ureteric epithelial progenitor cells. In certain embodiments, identification of viable nephron progenitor cells and or ureteric epithelial progenitor cells includes measurement or detection of co- expression of a plurality of nucleic acids and/or proteins as markers for the viable nephron and/or ureteric epithelial progenitor ceils. In another aspect, the invention provides isolated, enriched or purified nephron and/or ureteric epithelial progenitor cells produced according to the method of the aforementioned aspect. in yet another aspect, the invention provides a method of producing a kidney, or kidney ceils or tissues, said method including the step of differentiating kidney, or kidney cells or tissues from the nephron progenitor cells and/or ureteric epithelial progenitor ceils of the aforementioned aspect to thereby produce the kidney, or kidney cells or tissues. In some embodiments, the nephron progenitor cells and/or ureteric epithelial progenitor cells may be used as a source for bioprinting or bio -engineering whole kidneys and kidney tissue for kidney transplant or treating chronic kidney disease. In other embodiments, the nephron progenitor cells and/or ureteric epithelial progenitor cells may be used for the recelkslarisaiion of whole organ decellularised kidney to thereby create a reconstituted or replacement kidney. in other embodiments, the nephron progenitor ceils and/or ureteric epithelial progenitor cells may be used as a source for cellular therapy of kidney diseases and conditions. In a further aspect, the invention provides a method of determining the nephrotoxicity of one or a .plurality of compounds, said method including the step of contacting the one or plurality of compounds with the isolated or purified nephron progenitor cells and/or ureteric epithelial progenitor cells of the aforementioned aspect, or kidne cells or tissues differentiated or otherwise obtained therefrom, to thereby determine whether or not the one or plurality of compounds is nephrotoxic. In one embodiment, this aspect provides bioprinting of the nephron progenitors and/or ureteric epithelial progenitors into kidney organoids for nephrotoxicity screening. BRIEF DESCRIPTION OF THE FIGURES Figure L Sequential differentiation of posterior primitive streak and intermediate mesoderm from human embryonic stem cells, a. Schematic of developmental stages from inner cell mass to renal lineages. Genes shown in each stage represent specific markers of that stage. b ? F.ACS analysis (GFP and forward scatter (FSC)) showing the percentage of MlXLi-GFF positive posterior primitive streak cells induced with different ratios of BMP4/Activm A (ng rnL) or 8 μ of CHIR99Q21 after 3 days culture. hESC, starting cells; No GFs, 3 days culture with basal media, c, d. Relative expressions of SOX17, BRACHYURY (T) and MIXLl at day 3 for each ratio of BMP4 nd Activin A (ng/mL). assessed by qRT-PCR analysis