Methods For Detecting And Reversing Resistance To Macrocyclic Lactone Compounds


This invention describes nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds, and their expression product. Also described are methods for detecting the gene encoding for resistance to the macrocyclic lactone compounds in nematode or arthropod pests which comprise comparing nucleic acids extracted from a pest specimen to those encoding for resistance and susceptibility to the pesticides. The invention is further drawn to methods and compositions for increasing the efficacy of the macrocyclic lactone compounds against resistant nematode or resistant arthropod pests which comprise administering to a mammal or applying to crops an effective amount of a multidrug resistance reversing agent.

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Document History
  • Publication: Nov 5, 1998
  • Application: Apr 29, 1998
    WO IB 9800735 W
  • Priority: Apr 28, 1998
    US US 6767698 A
  • Priority: Apr 30, 1997
    US US 4516097 P

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