Abstract

Composition containing a microorganism, preferably an Archaea, expressing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein, capable of metabolizing trimethylamine (TMA) in the presence of hydrogen in a human cavity, such as the intestine or the vagina, for use as a medicament for treating, reducing or eliminating TMA at the level of the human cavity. In addition, a composition containing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein. These compositions are of use for treating trimethylaminuria, for treating vaginal fluids in the case of bacterial vaginosis and for reducing or eliminating odours due to TMA. These compositions are also of use for reducing the level of plasma TMAO, for preventing the formation of atheroma plaques and/or for preventing cardiovascular diseases.


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Owners (US)

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Document History
  • Publication: Mar 26, 2019
  • Application: Sep 27, 2013
    US US 201314648186 A
  • Priority: Sep 27, 2013
    EP EP 2013070249 W
  • Priority: Jul 15, 2013
    FR FR 1356937 A
  • Priority: Mar 13, 2013
    FR FR 1352239 A
  • Priority: Nov 30, 2012
    FR FR 1261507 A

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