{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"094-187-186-319-434","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"094-187-186-319-434"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11868,"type":"PATENT","title":"University of South Carolina - Columbia Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":6717,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8472,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
(A) a heavy chain variable domain comprising a CDRH1, a CDRH2 and a CDRH3, wherein the CDRH1 comprises the amino acid sequence of SEQ ID NO:147, the CDRH2 comprises the amino acid sequence of SEQ ID NO:163, and the CDRH3 comprises the amino acid sequence of SEQ ID NO:186; and\n
(B) a light chain variable domain comprising a CDRL1, a CDRL2 and a CDRL3, wherein the CDRL1 comprises the amino acid sequence of SEQ ID NO:193; the CDRL2 comprises the amino acid sequence of SEQ ID NO:214 and the CDRL3 comprises the amino acid sequence of SEQ ID NO:228."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The antibody or fragment of claim 1 that has one or more of the following characteristics:\n
(A) is a monoclonal antibody;\n
(B) is a chimeric, a humanized or a fully human antibody;\n
(C) is an antibody of the IgG1-, IgG2-, IgG3- or IgG4-type;\n
(D) is a Fab fragment, a Fab′ fragment, an F(ab′)2 fragment, or an Fv fragment;\n
(E) is labeled."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["An isolated antibody or fragment thereof that binds human c-fms, wherein the antibody or fragment comprises:\n
(A) a heavy chain variable domain comprising the amino sequence of SEQ ID NO:77; and\n
(B) a light chain variable domain comprising the amino acid sequence of SEQ ID NO:110."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The antibody or fragment thereof of claim 3 that has one or more of the following characteristics:\n
(A) is a monoclonal antibody;\n
(B) is a chimeric, a humanized or a fully human antibody;\n
(C) is an antibody of the IgG1-, IgG2-, IgG3- or IgG4-type;\n
(D) is a Fab fragment, a Fab′ fragment, an F(ab′)2 fragment, or an Fv fragment;\n
(E) is labeled."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["An isolated, fully human, monoclonal antibody comprising a heavy chain and a light chain, wherein the heavy chain comprises the amino acid sequence of SEQ ID NO:11 and the light chain comprises the amino acid sequence of SEQ ID NO:44."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["An isolated antibody or antibody fragment that competes with the antibody or fragment of claim 3 for binding to the extracellular domain of human c-fms of SEQ ID NO:1."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A composition comprising the antibody or fragment of claim 1 and a pharmaceutically acceptable diluent or carrier."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A composition comprising the antibody or fragment of claim 3 and a pharmaceutically acceptable diluent or carrier."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["A composition comprising the antibody of claim 5 and a pharmaceutically acceptable diluent or carrier."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A composition comprising the antibody or fragment of claim 6 and a pharmaceutically acceptable diluent or carrier."],"number":10,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}