A Two-component Taxane Containing Pharmaceutical Composition

  • Published: Jul 31, 2008
  • Earliest Priority: Jan 23 2007
  • Family: 3
  • Cited Works: 0
  • Cited by: 1
  • Cites: 6
  • Additional Info: Full text
Abstract

A two-component taxane containing pharmaceutical composition useful for the preparation of infusion solutions wherein decomposition and/or precipitation of taxane derivatives from the infusion solutions is avoided, said composition comprising a) taxane derivative solution in ethanol and b) a solution of a surfactant selected from polysorbates or polyoxyethylated castor oil (polyoxyethyleneglycerol triricinoleate) in ethanol or a mixture of ethanol and water. Said pharmaceutical composition is stable, easy to prepare and easy to use. A method for the preparation of an infusion solution comprising taxane derivatives, which comprises i) mixing components a) a b) as identified above and then ii) diluting the premix from step i) with a common unloaded infusion solution. Taxane containing pharmaceutical compositions according to the invention are particularly useful for the treatment of cancer.


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Document History
  • Publication: Jul 31, 2008
  • Application: Oct 19, 2007
    WO CZ 2007000092 W
  • Priority: Jan 23, 2007
    CZ CZ 200756 A

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