{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"092-240-186-114-591","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"092-240-186-114-591","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11682,"type":"PATENT","title":"Zhejiang University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":50796,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8338,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
a sensitive functional unit comprising:\n
a substrate having a first opening extending through the substrate; and\n
a sub-nanometer-thick functional layer disposed on the substrate, the sub-nanometer-thick functional layer having a nanopore extending through the sub-nanometer-thick functional layer, the sub-nanometer-thick functional layer made of an insulating material having a layered structure comprising boron nitride, graphene oxide, or hydrogenated graphene; and\n
a micro-nanofluidic device comprising:\n
a first micro-nanometer separation channel connected to a first side of the sensitive functional unit;\n
a first fluidic reservoir connected to the first micro-nanometer separation channel;\n
a first electrophoresis electrode or micropump connected to the first fluidic reservoir;\n
a second micro-nanometer separation channel connected to a second side of the sensitive functional unit opposite to the first side;\n
a second fluidic reservoir connected to the second micro-nanometer separation channel;\n
a second electrophoresis electrode or micropump connected to the second fluidic reservoir; and\n
a first electrode located in the first micro-nanometer separation channel and a second electrode located in the second micro-nanometer separation channel for measuring ionic current, the first micro-nanometer separation channel comprising a first micrometer dimension channel or a first nanometer dimension channel, the second micro-nanometer separation channel comprising a second micrometer dimension channel or a second nanometer dimension channel."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 1, wherein the insulating material having a layered structure comprises from about 1 to about 100 layers."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 1, wherein the nanopore has a circular, elliptical, or polygonal shape with a dimension of from about 1 to about 100 nm."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 1, wherein the first opening has a circular, elliptical, or polygonal shape with a dimension larger than the nanopore."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 1, wherein the substrate is made of a semiconductor or an insulating material."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 5, wherein the semiconductor material is Si, GaN, Ge, GaAs, or a combination thereof, and wherein the insulating material is SiC, Al2O3, SiNx, SiO2, HfO2, polyvinyl alcohol, poly(4-vinylphenol), polymethylmethacrylate, or a combination thereof."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 1, wherein the first fluidic reservoir, the first micro-nanometer separation channel, the first opening, the nanopore, the second micro-nanometer separation channel, and the second fluidic reservoir are aligned along a common central axis."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 1, wherein the sensitive functional unit further comprises:\n
a first electrically insulating layer sandwiched between the substrate and a first surface of the sub-nanometer-thick functional layer, the first electrically insulating layer having a second opening extending through the first insulating layer."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 8, wherein the second opening has a circular, elliptical, or polygonal shape with a dimension larger than the nanopore."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 8, wherein the first electrically insulating layer is made of SiO2, Al2O3, BN, SiC, SiNx, HfO2, polyvinyl alcohol, poly(4-vinylphenol), or a combination thereof."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 8, wherein the first fluidic reservoir, the first micro-nanometer separation channel, the first opening, the second opening, the nanopore, the second micro-nanometer separation channel, and the second fluidic reservoir are aligned along a common central axis."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 1, wherein the sensitive functional unit further comprises:\n
a second electrically insulating layer disposed on a second surface of the sub-nanometer-thick functional layer opposite the substrate, the second electrically insulating layer having a third opening extending through the second insulating layer."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 12, wherein the third opening has a circular, elliptical, or polygonal shape with a dimension larger than the nanopore."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 12, wherein the second electrically insulating layer is made of SiO2, Al2O3, BN, SiC, SiNx, HfO2, polyvinyl alcohol, poly(4-vinylphenol), or a combination thereof."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 12, wherein the first fluidic reservoir, the first micro-nanometer separation channel, the first opening, the nanopore, the third opening, the second micro-nanometer separation channel, and the second fluidic reservoir are aligned along a common central axis."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor with a sub-nanometer-thick functional layer of claim 1, wherein the sensitive functional unit further comprising:\n
a first electrically insulating layer sandwiched between the substrate and a first surface of the sub-nanometer-thick functional layer, the first electrically insulating layer having a second opening extending through the first insulating layer; and\n
a second electrically insulating layer disposed on a second surface of the sub-nanometer-thick functional layer opposite the first surface, the second electrically insulating layer having a third opening extending through the second insulating layer."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 16, wherein the second opening and the third opening have a circular, elliptical, or polygonal shape with a dimension larger than the nanopore, respectively."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 16, wherein the first electrically insulating layer and the second electrically insulating layer is made of the same or different materials comprising SiO2, Al2O3, BN, SiC, SiNx, HfO2, polyvinyl alcohol, poly(4-vinylphenol), or a combination thereof."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The nanopore sensor of claim 16, wherein the first fluidic reservoir, the first micro-nanometer separation channel, the first opening, the second opening, the nanopore, the third opening, the second micro-nanometer separation channel, and the second fluidic reservoir are aligned along a common central axis."],"number":19,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}