Ester Derivatives


This invention relates to compounds which exhibit selective muscarinic M3 receptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I); [in which A signifies a group expressed by a formula (a0) or (b0); Ar signifies optionally substituted aryl or heteroaryl; B1 and B2 signify aliphatic hydrocarbon; R1 signifies fluorine-substituted cycloalkyl; R2, R3 and R4 signify lower alkyl, single bond or alkylene bonded to B1, or R2 and R3 are united to signify alkylene; R5 and R7 signify hydrogen, lower alkyl, or a single bond or alkylene bonded to B2; R6 signifies hydrogen, lower alkyl or a group expressed as -N(R8)R9; and X- signifies an anion].

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Document History
  • Publication: Mar 17, 2009
  • Application: Jan 3, 2007
    US US 64861407 A
  • Priority: Jan 3, 2007
    US US 64861407 A
  • Priority: Nov 9, 2004
    US US 98361304 A
  • Priority: Jan 10, 2003
    US US 33261703 A
  • Priority: Jul 10, 2001
    JP 0105987 W
  • Priority: Jul 11, 2000
    JP 2000210591 A

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