{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"089-694-171-086-629","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"089-694-171-086-629","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8905,"type":"PATENT","title":"SFIT Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4158,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8220,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners = \"Swiss Federal Institute of Technology\",\"Swis* Fed* Inst* Tech*\" , \"ETH Zurich\", \"ETH Transfer\", \"ETH\".
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Total patents: 2709
Search applicants and owners = \"Swiss Federal Institute of Technology\",\"Swis* Fed* Inst* Tech*\" , \"ETH Zurich\", \"ETH Transfer\", \"ETH\".
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Total patents: 2709
(a) administering to the human or animal an antibody which binds the ED-A isoform of fibronectin, and
(b) determining the presence or absence of the antibody in the lymphatic system of the human or animal body;wherein localisation of the antibody to the lymphatic system in the human or animal indicates the presence of a lymphoma."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["An antibody that binds the ED-A isoform of fibronectin for use in a method of delivering a molecule conjugated to the antibody to the neovasculature of a lymphoma in a human or animal."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The use of an antibody that binds the ED-A isoform of fibronectin for the preparation of a medicament for delivery to a lymphoma of a molecule conjugated to the antibody."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["An antibody for use according to any one of claims 2 to 4, or the use of claim 5, wherein the molecule is a detectable label."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["An antibody for use according to claim 4, or the use of claim 5, wherein the molecule has biocidal or cytotoxic activity, or is a radioisotope."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["An antibody for use according to any one of claims 1 to 4, 6 or 7, or the use of any one of claims 5 to 7, wherein the antibody binds the ED-A of fibronectin."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["An antibody for use according to any one of claims 1 to 4 or 6 to 8, or the use of any one of claims 5 to 8, wherein the lymphoma is Hodgkin's lymphoma or non-Hodgkin's lymphoma."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["An antibody for use according to any one of claims 1 to 4 or 6 to 9, or the use of any one of claims 5 to 9, wherein the antibody comprises a VH domain and a VL domain, wherein the VH domain comprises a framework and a set of complementarity determining regions HCDR1, HCDR2 and HCDR3, and wherein the VL domain comprising a set of complementarity determining regions LCDR1, LCDR2 and LCDR3 and a framework, wherein:
HCDR1 has amino acid sequence SEQ ID NO: 83,
HCDR2 has amino acid sequence SEQ ID NO: 4,
HCDR3 has amino acid sequence SEQ ID NO: 5;
LCDR1 has amino acid sequence SEQ ID NO: 86,
LCDR2 has amino acid sequence SEQ ID NO: 7, and
LCDR3 has amino acid sequence SEQ ID NO: 8."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["An antibody for use according to claim 10, or the use of claim 10, wherein the VH domain framework and/or the VL domain framework is a human germline framework."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["An antibody for use according to claim 10 or 11, or the use of claim 10 or 11, wherein the antibody either comprises the VH domain shown in SEQ ID NO: 81; or comprises the VH domain shown in SEQ ID NO: 81, except that the amino acid at position 5 of the VH domain is a leucine residue (L) rather than a valine residue (V)."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["An antibody for use according to any one of claims 10 to 12, or the use of any one of claims 10 to 12, wherein the antibody either comprises the VL domain shown in SEQ ID NO: 82; or comprises the VL domain shown in SEQ ID NO: 82, except that the amino acid at position 18 of the VL domain is an arginine residue (R) rather than a lysine residue (K)."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["An antibody for use according to any one of claims 1 to 4 or 6 to 13, or the use of any one of claims 5 to 13, wherein the antibody is a single chain Fv or a diabody."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["An antibody for use according to any one of claims 1 to 4 or 6 to 14, or the use of any one of claims 5 to 14, wherein the antibody is a single chain Fv or diabody comprising the VH domain shown in SEQ ID NO: 81, except that the amino acid at position 5 of the VH domain is a leucine residue (L) rather than a valine residue (V), and further comprising the VL domain shown in SEQ ID NO: 82, except that the amino acid at position 18 of the VL domain is an arginine residue (R) rather than a lysine residue (K)."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["An in vitro method of diagnosing lymphoma, wherein an antibody that binds the ED-A of fibronectin is used."],"number":16,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}