Methods For Identifying An Increased Risk Of Anthracycline-related Cardiotoxicity

Abstract

Methods of identifying a subject having an increased risk of developing anthracycline-related cardiotoxicity are provided. Such methods may include isolating a DNA sample from a biological specimen from the subject; genotyping the DNA sample to determine a copy number of a variant allele that increases the risk of developing chemotherapy-induced cardiotoxicity; and identifying the subject as having an increased risk of developing anthracycline-related cardiotoxicity when the copy number is at least one. In some embodiments, the methods may include optimally administering a therapeutically effective dose of a chemotherapy agent or an alternative non-cardiotoxic chemotherapeutic agent to the subject.


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Document History
  • Publication: May 16, 2017
  • Application: Dec 9, 2013
    US US 201314101006 A
  • Priority: Dec 9, 2013
    US US 201314101006 A
  • Priority: Dec 7, 2012
    US US 201261734778 P

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