Combination Therapy, Composition And Methods For The Treatment Of Cardiovascular Disorders

  • Published: Sep 4, 2008
  • Earliest Priority: Feb 26 2007
  • Family: 12
  • Cited Works: 0
  • Cited by: 1
  • Cites: 0
  • Additional Info: Full text
Abstract

The present invention relates to a combination therapy for the treatment of cardiovascular disorders. More particularly, the invention relates to compositions combining long-chain optionally substituted amphipatic carboxylates (known as MEDICA drugs) and particularly, M16aa, M16ßß and M18??, with HMG-CoA reductase inhibitors (known as statins). The compositions of the invention may particularly be used for the treatment of cardiovascular disorders, for elevating HDL-cholesterol levels, decreasing non-HDL-cholesterol and particularly triglycerides, and decreasing insulin resistance in a subject suffering from Metabolic Syndrom or cardiovascular disorders. The invention further provides methods of treatment of such disorders using these combined compositions.


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