Substituted Cinnolines As Inhibitors Of Lrrk2 Kinase Activity

Abstract

The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.


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Document History
  • Publication: Feb 6, 2018
  • Application: May 21, 2012
    US US 201214122199 A
  • Priority: May 21, 2012
    US US 201214122199 A
  • Priority: May 21, 2012
    US US 2012/0038871 W
  • Priority: May 23, 2011
    US US 201161519443 P

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