Gene Encoding A Guanine Nucleotide Exchange Factor And The Gene Product Thereof

Abstract

A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.


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Document History
  • Publication: Feb 23, 2010
  • Application: Mar 29, 2005
    US US 59470705 A
  • Priority: Mar 29, 2005
    JP 2005005918 W
  • Priority: Mar 31, 2004
    JP 2004106268 A

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