{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"082-469-563-752-154","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"082-469-563-752-154","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8876,"type":"PATENT","title":"Northwestern University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":17491,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8210,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and Owners separately = \" Northwestern University\", 'Northw* Univ*\" , \"Univ Northwestern\", \"
Search applicants and Owners separately = \" Northwestern University\", 'Northw* Univ*\" , \"Univ Northwestern\", \"
providing a peptide conjugate compound comprising a bioactive agent; a peptide component comprising at least one of a lysinyl and a glutaminyl substrate for a transglutaminase; and a component coupling said agent to said peptide; and\n
contacting said compound and a tissue substrate comprising at least one of a lysinyl and a glutaminyl substrate for a transglutaminase, said contact in the presence of a transglutaminase enzyme, each of said contact and said enzyme presence at least partially sufficient to bind said compound and said tissue substrate."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19 wherein said enzyme is endogenous to said tissue."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19 wherein said compound comprises a cleavable coupling component, and cleavage thereof releases said agent from said compound."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 21 wherein said coupling component comprises a hydrolysable moiety."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19 wherein said tissue substrate comprises an ECM component."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["A method of using transglutaminase activity to deliver a therapeutic agent, said method comprising:\n
providing a peptide conjugate compound comprising a prodrug component of a therapeutic agent; a peptide component comprising at least one of a lysinyl and a glutaminyl substrate for a transglutaminase; and a component coupling said agent to said peptide, said coupling component hydrolysable under physiological conditions;\n
contacting said compound and a tissue substrate comprising at least one of a lysinyl and a glutaminyl substrate for a transglutaminase, said contact in the presence of a transglutaminase enzyme, each of said contact and said enzyme presence at least partially sufficient to bind said compound and said tissue substrate; and\n
hydrolyzing said compound, to release said therapeutic agent from said compound."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 24 wherein said compound comprises a prodrug of a glucocorticoid."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 25 wherein said glucocorticoid is hydrocortisone."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 24 wherein said compound is coupled to one of a cartilage tissue and a meniscus tissue."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 27 wherein said enzyme is endogenous to said tissue substrate."],"number":28,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}