Inhibition Or Erythrocyte Sickling By N-l-alpha-aspartyl-l-phenylalanine 1-methyl Ester

Abstract

It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) exhibits antisickling properties. In vitro testing verified that APM significantly lowered the frequency of sickling of red blood cells from each of twelve pediatric aged patients being treated for sickle-cell anemia by exchange transfusion. Sickling was also inhibited in an "index" patient after oral administering of APM. These in vitro and in vivo results identify APM as a therapeutic agent for the family of sickle cell molecular diseases.


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Document History
  • Publication: May 7, 2002
  • Application: Mar 22, 2001
    US US 78799401 A
  • Priority: Mar 22, 2001
    US US 78799401 A
  • Priority: Sep 25, 1999
    US US 9922268 W
  • Priority: Sep 25, 1998
    US US 10187698 P

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