Global Proteomic Screening Of Random Bead Arrays Using Mass Spectrometry Imaging

Abstract

Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.


Claims
Download PDF
Document Preview
Document History
  • Publication: Dec 20, 2016
  • Application: Jun 29, 2011
    US US 201113172164 A
  • Priority: Jun 29, 2011
    US US 201113172164 A
  • Priority: Jun 30, 2010
    US US 35996410 P

Download Citation


Sign in to the Lens

Feedback