{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"078-604-387-161-797","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"078-604-387-161-797"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":12117,"type":"PATENT","title":"Okayama University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2257,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8622,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Okayama Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2257
Search Applicants and Owners separately:Okayama Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2257
PROBLEM TO BE SOLVED: To establish a stable human cell strain having resistance to highly concentrated gefitinib; to provide a method for simply screening a medicine for treating lung cancer having T790M mutation in EGFR gene with the cell strain; and to offer the cell strain to the analysis of acquired resistance mechanism.
SOLUTION: A gefitinib-resistant strain is obtained by repeating the culture of a human non-small cell lung cancer cell strain PC-9 in a culture medium whose gefitinib concentration is gradually enhanced. The resistant cell strain inhibits the signaling of EGFR and has T790M mutation in EGFR gene.
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