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Abstract

The invention discloses a method for determining correlation between a single nucleotide polymorphism rs6887695 of IL-12b gene of Chinese Han people and systemic lupus erythematosus. Through the combination of high resolution melting analysis (HRMA) and a non-labeled probe, all genotypes are distinguished successfully. A result obtained by the method shows that based on Chinese Han people suffering from systemic lupus erythematosus, the IL-12b gene is related to a systemic lupus erythematosus incidence risk and also is related to arthritis and autoantibody production. The method provides an important basis for further research on systemic lupus erythematosus pathogenesis.


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Document History
  • Publication: Apr 3, 2013
  • Application: Sep 23, 2011
    CN CN 201110285691 A
  • Priority: Sep 23, 2011
    CN CN 201110285691 A

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