{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"077-414-062-231-896","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"077-414-062-231-896"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11746,"type":"PATENT","title":"University of Turin Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":371,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8385,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: uni* AND Torino. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 348
Search Applicants and Owners separately: uni* AND Torino. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 348
i) preparing a transgenic parent animal carrying an inactivated melusin allele;
ii) breeding the parent transgenic mammal with a non transgenic mammal;
iii) selecting transgenic mammals heterogyzote for the melusin gene mutation."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["Method according to claim 22, further comprising the step of iv) breeding the heterozygote transgenic mammals to select homozygote transgenic mammals for the melusin gene mutation."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["Method for screening compounds able to interact with melusin, said compounds being melusin agonists and pharmacologically active in the prevention and/or treatment of heart failure, wherein said method comprises using melusin, fragments and/or derivatives thereof."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["Use of melusin, fragments and/or derivatives thereof for the manufacture of a medicament for the prevention and/or treatment of heart failure."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["Use of melusin, fragments and/or derivatives thereof for the screening of compounds pharmacologically active for the prevention and/or treatment of heart failure."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["Use according to claim 26, wherein said pharmacologically active compound is a melusin agonist."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["Use of a DNA vector for the manufacture of a medicament for use in the prevention and/or treatment of heart failure, said vector comprising a transgene coding for the melusin protein or fragments thereof and expressing said transgene in the myocardium."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["Use according to claim 28, wherein said transgene comprises melusin cDNA or fragments thereof."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["Use according to any claim 28 to 29, wherein said vector is an adenoviral vector or a lentiviral vector."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["Pharmaceutical compositions comprising melusin, fragments and/or derivatives thereof for the prevention and/or treatment of heart failure."],"number":31,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}