Sieve Valves, Microfluidic Circuits, Microfluidic Devices, Kits, And Methods For Isolating An Analyte


One aspect of the invention provides a sieve valve including: a substrate defining a channel; a flexible membrane adapted and configured for deployment at an intersection with the channel; and one or more protrusions extending into the channel from the substrate or the flexible membrane. The one or more protrusions define a plurality of recesses extending beyond the intersection between the channel and the flexible membrane.


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