Peptides And Methods For The Control Of Obesity


The subject invention provides novel peptides for use in treating mammals to control appetite and obesity. Disclosed is a peptide derivative having the formula: <?in-line-formulae description="In-line Formulae" end="lead"?>X<SUP>1</SUP>-Z-Q-arg-trp-NH<SUB>2</SUB><?in-line-formulae description="In-line Formulae" end="tail"?> wherein: X<SUP>1 </SUP>is an acyl group, Z is amino-2-naphthyl-carboxylic acid or histidine, Q is (D)phenylalanine or p-iodo-(D)phenylalanine, or a pharmacologically acceptable salt, complex or derivative thereof, the peptide derivative having melanocortin-4 receptor agonist activity.

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Document History
  • Publication: May 6, 2008
  • Application: Nov 8, 2005
    US US 26892605 A
  • Priority: Nov 8, 2005
    US US 26892605 A
  • Priority: May 7, 2002
    US US 13962402 A

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