{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"076-409-174-484-633","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"076-409-174-484-633"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11746,"type":"PATENT","title":"University of Turin Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":371,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8385,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: uni* AND Torino. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 348
Search Applicants and Owners separately: uni* AND Torino. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 348
(a) putting in contact a test agent with PI3Kβ protein or a fragment thereof, or cells expressing said PI3Kβ protein or fragment thereof,
(b) measuring PI3Kβ protein activity, function, stability and/or expression, and
(c) selecting the agent that reduces PI3Kβ protein activity, function, stability and/or expression, wherein said selected agent is useful in the treatment of a HER2 positive breast cancer."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["Method according to claim 7, wherein said step a) comprises putting in contact a test agent with PI3Kβ protein or a fragment thereof, or cells expressing said PI3Kβ protein or fragment thereof in presence of a suitable endogenous and/or exogenous substrate for PI3Kβ protein."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["Method according to claim 8, wherein said substrate is phosphatidyl inositole."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["Method according to any one of claims 7 to 9, wherein said measuring in step b) comprises measuring cell signalling, cell survival, cell proliferation, and/or phosphorylation of the substrate."],"number":10,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}