Epigenetic Regulatory Complex For Control Of Gene Expression

Abstract

An epigenetic regulatory polypeptide complex comprises at least a first domain having site-specific DNA binding activity and at least a second domain having an arginine methyltransferase activity, wherein the second domain is capable of methylating an arginine residue located in the tail region of a histone H2A. The complex is able to regulate gene expression in cells, particularly in mammalian stem cells by controlling the methylation of R3 in the tail regions of histones H2A and H4. The complex is exemplified by a polypeptide complex comprising the DNA binding activity of Blimpi and the arginine methyltransferase activity of Prmt5.


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Document History
  • Publication: Nov 15, 2007
  • Application: May 8, 2007
    WO GB 2007001688 W
  • Priority: May 5, 2006
    GB GB 0608945 A
  • Priority: May 5, 2006
    US US 79802906 P

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