Targeting Ncca-atp Channel For Organ Protection Following Ischemic Episode

Abstract

The present invention concerns protection of an organ or tissue outside of the central nervous system following an ischemic episode. In particular aspects, the invention concerns organ preservation for transplantation, angina pectoris, kidney reperfusion injury, and so forth. In specific embodiments, the organ is subjected to an inhibitor of an NCCa-ATP channel that is regulated by SUR1. Exemplary inhibitors include sulfonylurea compounds, such as glibenclamide, for example.


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Document History
  • Publication: Jan 1, 2019
  • Application: Dec 5, 2016
    US US 201615369056 A
  • Priority: Dec 5, 2016
    US US 201615369056 A
  • Priority: Jan 27, 2010
    US US 52244410 A
  • Priority: Jan 11, 2008
    US US 2008/0050922 W
  • Priority: Dec 10, 2007
    US US 1261307 P
  • Priority: Jul 27, 2007
    US US 95239607 P
  • Priority: Apr 13, 2007
    US US 92337807 P
  • Priority: Jan 12, 2007
    US US 88011907 P

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