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L'invention concerne une méthode pour identifier un gène requis pour la prolifération in vivo d'un microorganisme pathogène, comprenant- l'utilisation d'une souche du microorganismes pathogène,- la génération de mutants d'inactivation dans les gènes codant pour ces facteurs,- la détermination de la virulence de ces mutants sur modèle expérimental d'infection, et de leur effet sur la colonisation entérique chez un modèle de souris axénique, et- la sélection des gènes bactériens essentiels pour la résistance au sérum in vitro, et essentiels chez l'hôte pour la dissémination sérique.Application au criblage de composés inhibiteurs des produits des gènes identifiés et à l'inhibition in vitro de la prolifération d'un mircroorganisme pathogène dans le sérum.
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