{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"074-030-083-582-407","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"074-030-083-582-407"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11620,"type":"PATENT","title":"Icahn School of Medicine at Mount Sinai - Patent Portfoilo","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3154,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8295,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: Icalh* medici*
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Select all patents in the collection and expand by simple families. Add to collection. Total patents: 896
Search Applicants and Owners separately: Icalh* medici*
Select more for logical variants. Add to collection.
Select all patents in the collection and expand by simple families. Add to collection. Total patents: 896
(i) contacting an isolated cell expressing the TRP8 channel protein of SEQ ID NO: 4 with a test compound and measuring the level of TRP8 activation;\n
(ii) in a separate experiment, contacting an isolated cell expressing the TRP8 channel protein of SEQ ID NO: 4 with a vehicle control and measuring the level of TRP8 activation where the conditions are essentially the same as in part (i); and\n
(iii) comparing the level of activation of TRP8 measured in part (i) with the level of activation of TRP8 in part (ii),\n
wherein the level of TRP8 activation is measured by measuring the membrane potential of the cell and wherein an increased level of activated TRP8 in the presence of the test compound indicates that the test compound potentially induces the perception of a bitter taste."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein said measuring the level of TRP8 activation is carried out with one or more fluorescence-indicator dyes."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein said measuring the membrane potential of the cell is carried out under voltage clamp assay conditions."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein said measuring the membrane potential of the cell is carried out under patch recording assay conditions."],"number":4,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}