Aryl Alkenamides Derivatives As Mcp-1 Antagonists


Aryl alkenamides derivatives of Formula I or a pharmaceutically acceptable salt thereof are novel MCP-1 antagonists and are thus useful in the treatment of inflammation, atherosclerosis, restenosis, and immune disorders such as arthritis and transplant rejectionwhereV=O,S, NH or a bond;Ar can be unsubstituted or substituted benzimidazole, phenyl, biphenyl, pyridyl, naphthyl, quinoline or isoquinoline. The other meanings for the terms are recited in the specification below.

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Document History
  • Publication: Oct 1, 2002
  • Application: Aug 12, 1997
    US US 90979097 A
  • Priority: Aug 12, 1997
    US US 90979097 A
  • Priority: Aug 15, 1996
    US US 2396696 P

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