Prmt1 For Target Genes Of Cancer Therapy And Diagnosis

Abstract

Objective methods for diagnosing a predisposition to developing cancer, particularly bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer, are described herein. In one embodiment, the diagnostic method involves determining an expression level of PRMT1 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRMT1 associated disease, such as a cancer, e.g. bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of PRMT1 associated diseases. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions comprising them.


Claims
Download PDF
Document Preview
Document History
  • Publication: Aug 20, 2013
  • Application: Aug 25, 2009
    US US 200913060672 A
  • Priority: Aug 25, 2009
    US US 200913060672 A
  • Priority: Aug 25, 2009
    JP 2009004091 W
  • Priority: Aug 27, 2008
    US US 19041608 P

Download Citation


Sign in to the Lens

Feedback