Compounds And Methods For Modulating Apolipoprotein C-iii Expression For Improving A Diabetic Profile

Abstract

Provided herein are improved compounds, compositions and associated methods for reducing expression of ApoCIII mRNA and protein in a subject having, or at risk of having, diabetes. Also provided herein are compounds, compositions and associated methods improving peripheral insulin sensitivity, a lipid profile and a diabetes profile as well as reducing free fatty acids and intramyocellular triglyceride deposition.


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Document History
  • Publication: Mar 6, 2018
  • Application: Jun 23, 2014
    US US 201414900320 A
  • Priority: Jun 23, 2014
    US US 201414900320 A
  • Priority: Jun 23, 2014
    US US 2014/0043723 W
  • Priority: Jun 21, 2013
    US US 201361838211 P

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