Abstract

Polyenv immunogenic composition are provided that comprise mixtures of at least 4 different recombinant viruses that each express a different HIV env variant or a portion thereof containing both constant and variable regions, as well as methods of making and using such polyenv immunogenic composition and viruses. The immunogenic composition of the invention are optimally combined with a recombinant HIV env booster, or a recombinant HIV env gene DNA priming or boosting vaccine.


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Document History
  • Publication: Dec 8, 1998
  • Application: Jan 23, 1997
    US US 78881597 A
  • Priority: Jan 23, 1997
    US US 78881597 A
  • Priority: Jan 23, 1996
    US US 59028896 A

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