EP 2077274 A1 - Synthetic Analogs Of Human Beta-defensins Having Antimicrobial, Antiviral And Chemotactic Activity - The Lens

Synthetic Analogs Of Human Beta-defensins Having Antimicrobial, Antiviral And Chemotactic Activity

Published: Jul 8, 2009
Earliest Priority: Jan 02 2008
Family: 3
Cited Works: 46
Cited by: 3
Cites: 1
Sequences: 20
Additional Info: Cited Works Published Sequence

Data obtained from: EMBL-EBI Pat

20 sequences found in this patent (in total)

Download sequences in fasta format: 20 peptides

Displaying 1 - 10 of 20 sequences

SEQ ID NO

Length

Sequence Type

Locations

Declared organism

Determined organism

Occurrence

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Homo sapiens
Homo sapiens
Public DB hit
GI:4885181
NP_005209
1 of 14 hits reported for Homo sapiens.

Hit length
68 aa

E Value
6.01E-13

BLAST Score
78.2 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
NP_005209

52.94% cov

Alignment Length
36 aa

CIGAR string
36M mismatches: 0 - insertions: 0 - deletions: 0
Pan troglodytes
Pan troglodytes
Public DB hit
GI:152060597
P60023

Hit length
68 aa

E Value
8.33E-12

BLAST Score
74.3 bits

Similarity

97.22%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
P60023

52.94% cov

Alignment Length
36 aa
Gorilla gorilla gorilla
Gorilla gorilla gorilla
Public DB hit
GI:61211666
Q95M68

Hit length
68 aa

E Value
9.36E-12

BLAST Score
74.3 bits

Similarity

97.22%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
Q95M68

52.94% cov

Alignment Length
36 aa
Nomascus leucogenys
Nomascus leucogenys
Public DB hit
GI:332244599
XP_003271461

Hit length
68 aa

E Value
3.27E-11

BLAST Score
72.4 bits

Similarity

97.22%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
XP_003271461

52.94% cov

Alignment Length
36 aa
Trachypithecus obscurus
Trachypithecus obscurus
Public DB hit
GI:61211581
Q7JGL9

Hit length
68 aa

E Value
3.8E-11

BLAST Score
72.4 bits

Similarity

94.44%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
Q7JGL9

52.94% cov

Alignment Length
36 aa
Cercopithecus preussi
Cercopithecus preussi
Public DB hit
GI:61211580
Q7JGL8

Hit length
68 aa

E Value
4.24E-11

BLAST Score
72 bits

Similarity

94.44%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
Q7JGL8

52.94% cov

Alignment Length
36 aa
Pongo abelii
Pongo abelii
Public DB hit
GI:297682219
XP_002818824

Hit length
68 aa

E Value
4.61E-11

BLAST Score
72 bits

Similarity

94.44%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
XP_002818824

52.94% cov

Alignment Length
36 aa
Macaca mulatta
Macaca mulatta
Public DB hit
GI:74136275
NP_001028029

Hit length
68 aa

E Value
7.17E-11

BLAST Score
71.2 bits

Similarity

94.44%

Coverage

100%

Alignment (schematic)

SEQ ID NO 1

100% cov
NP_001028029

52.94% cov

Alignment Length
36 aa

Occurrence

525 times in PatSeqDB

in 78 extended families
(11 referenced in claims)
in 97 simple families
(14 referenced in claims)
in 490 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Papio anubis
Papio anubis
Public DB hit
GI:31071997
DAA01350

Hit length
67 aa

E Value
8.16E-17

BLAST Score
90.9 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
DAA01350

67.16% cov

Alignment Length
45 aa

CIGAR string
45M mismatches: 0 - insertions: 0 - deletions: 0
Homo sapiens
Homo sapiens
Public DB hit
GI:8923890
NP_061131
1 of 4 hits reported for Homo sapiens.

Hit length
67 aa

E Value
9.02E-17

BLAST Score
90.9 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
NP_061131

67.16% cov

Alignment Length
45 aa

CIGAR string
45M mismatches: 0 - insertions: 0 - deletions: 0
Gorilla gorilla gorilla
Gorilla gorilla gorilla
Public DB hit
GI:152112316
A4H1Z9

Hit length
67 aa

E Value
9.64E-17

BLAST Score
90.9 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
A4H1Z9

67.16% cov

Alignment Length
45 aa

CIGAR string
45M mismatches: 0 - insertions: 0 - deletions: 0
Callithrix jacchus
Callithrix jacchus
Public DB hit
GI:296221581
XP_002756803

Hit length
77 aa

E Value
1.63E-16

BLAST Score
90.1 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
XP_002756803

58.44% cov

Alignment Length
45 aa
Pongo pygmaeus
Pongo pygmaeus
Public DB hit
GI:57019016
AAW32911

Hit length
47 aa

E Value
2.8E-16

BLAST Score
89.4 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
AAW32911

95.74% cov

Alignment Length
45 aa
Pan troglodytes
Pan troglodytes
Public DB hit
GI:193211435
NP_001123222
1 of 4 hits reported for Pan troglodytes.

Hit length
67 aa

E Value
4.36E-16

BLAST Score
88.6 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
NP_001123222

67.16% cov

Alignment Length
45 aa
Canis lupus familiaris
Canis lupus familiaris
Public DB hit
GI:194018734
NP_001123452

Hit length
67 aa

E Value
1.09E-13

BLAST Score
80.5 bits

Similarity

95.56%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
NP_001123452

67.16% cov

Alignment Length
45 aa
Ailuropoda melanoleuca
Ailuropoda melanoleuca
Public DB hit
GI:301789141
XP_002929984
1 of 2 hits reported for Ailuropoda melanoleuca.

Hit length
67 aa

E Value
5.56E-13

BLAST Score
78.2 bits

Similarity

97.78%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
XP_002929984

67.16% cov

Alignment Length
45 aa
Chinchilla lanigera
Chinchilla lanigera
Public DB hit
GI:48427992
P83943

Hit length
67 aa

E Value
9.82E-12

BLAST Score
74.3 bits

Similarity

91.11%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
P83943

67.16% cov

Alignment Length
45 aa
Bos taurus
Bos taurus
Public DB hit
GI:297468005
XP_002705534

Hit length
224 aa

E Value
2.88E-11

BLAST Score
72.8 bits

Similarity

90.91%

Coverage

97.78%

Alignment (schematic)

SEQ ID NO 2

97.78% cov
XP_002705534

19.64% cov

Alignment Length
44 aa
Sus scrofa
Sus scrofa
Public DB hit
GI:47523940
NP_999609

Hit length
67 aa

E Value
2.93E-11

BLAST Score
72.8 bits

Similarity

88.64%

Coverage

97.78%

Alignment (schematic)

SEQ ID NO 2

97.78% cov
NP_999609

65.67% cov

Alignment Length
44 aa

Occurrence

123 times in PatSeqDB

in 29 extended families
(9 referenced in claims)
in 31 simple families
(10 referenced in claims)
in 104 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

2 times in PatSeqDB

in 2 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

2 times in PatSeqDB

in 2 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

2 times in PatSeqDB

in 2 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Papio anubis
Papio anubis
Public DB hit
GI:31071997
DAA01350

Hit length
67 aa

E Value
4.2E-13

BLAST Score
78.6 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
DAA01350

58.21% cov

Alignment Length
39 aa

CIGAR string
39M mismatches: 0 - insertions: 0 - deletions: 0
Homo sapiens
Homo sapiens
Public DB hit
GI:8923890
NP_061131
1 of 4 hits reported for Homo sapiens.

Hit length
67 aa

E Value
4.27E-13

BLAST Score
78.6 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
NP_061131

58.21% cov

Alignment Length
39 aa

CIGAR string
39M mismatches: 0 - insertions: 0 - deletions: 0
Gorilla gorilla gorilla
Gorilla gorilla gorilla
Public DB hit
GI:152112316
A4H1Z9

Hit length
67 aa

E Value
4.3E-13

BLAST Score
78.6 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
A4H1Z9

58.21% cov

Alignment Length
39 aa

CIGAR string
39M mismatches: 0 - insertions: 0 - deletions: 0
Callithrix jacchus
Callithrix jacchus
Public DB hit
GI:296221581
XP_002756803

Hit length
77 aa

E Value
7.72E-13

BLAST Score
77.8 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
XP_002756803

50.65% cov

Alignment Length
39 aa
Pongo pygmaeus
Pongo pygmaeus
Public DB hit
GI:57019016
AAW32911

Hit length
47 aa

E Value
1.31E-12

BLAST Score
77 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
AAW32911

82.98% cov

Alignment Length
39 aa
Pan troglodytes
Pan troglodytes
Public DB hit
GI:193211435
NP_001123222
1 of 4 hits reported for Pan troglodytes.

Hit length
67 aa

E Value
1.82E-12

BLAST Score
76.6 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
NP_001123222

58.21% cov

Alignment Length
39 aa
Canis lupus familiaris
Canis lupus familiaris
Public DB hit
GI:194018734
NP_001123452

Hit length
67 aa

E Value
4.38E-10

BLAST Score
68.6 bits

Similarity

94.87%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
NP_001123452

58.21% cov

Alignment Length
39 aa
Bos taurus
Bos taurus
Public DB hit
GI:297468142
XP_002705694
1 of 3 hits reported for Bos taurus.

Hit length
152 aa

E Value
1.57E-9

BLAST Score
67 bits

Similarity

92.31%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
XP_002705694

25.66% cov

Alignment Length
39 aa
Ailuropoda melanoleuca
Ailuropoda melanoleuca
Public DB hit
GI:301789141
XP_002929984
1 of 2 hits reported for Ailuropoda melanoleuca.

Hit length
67 aa

E Value
2.32E-9

BLAST Score
66.2 bits

Similarity

97.44%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
XP_002929984

58.21% cov

Alignment Length
39 aa

Occurrence

6 times in PatSeqDB

in 2 families
in 6 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

2 times in PatSeqDB

in 2 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

2 times in PatSeqDB

in 2 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

2 times in PatSeqDB

in 2 documents

Tools

SEQ ID NO

Length

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

2 times in PatSeqDB

in 2 documents

Tools

20 sequences found in this patent (in total)

Filter sequences

Displaying 1 - 10 of 20 sequences

Homo sapiens

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

CIGAR string

Pan troglodytes

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Gorilla gorilla gorilla

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Nomascus leucogenys

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Trachypithecus obscurus

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Cercopithecus preussi

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Pongo abelii

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Macaca mulatta

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Papio anubis

Public DB hit

Hit length

E Value