{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"071-469-034-658-518","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"071-469-034-658-518"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10707,"type":"PATENT","title":"Duke Univ Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":9941,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8224,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately :' Duke Univ\"; \" Univ Duke\"; \" Uni* Duk*\"; \" Duk* Uni*\"; ' Duke University\" ; \" University Duke\".
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Search Applicants and Owners separately:\"Uni* Paris vi\";\"Uni* Paris 6\";\"Pierre Marie Curie Uni*\";\"Pie* Mar* Cur* Uni*\".
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Search Applicants and Owners separately :' Duke Univ\"; \" Univ Duke\"; \" Uni* Duk*\"; \" Duk* Uni*\"; ' Duke University\" ; \" University Duke\".
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 8489
Search Applicants and Owners separately:\"Uni* Paris vi\";\"Uni* Paris 6\";\"Pierre Marie Curie Uni*\";\"Pie* Mar* Cur* Uni*\".
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3587
(i) providing a radiation therapy free of cytotoxic chemotherapy by irradiating a tumor in a subject, wherein the radiation increases the number of tumor-associated macrophages, wherein the tumor-associated macrophages produce nitric oxide through inducible nitric oxide synthase, whereby the nitric oxide stabilizes HIF-1 in the irradiated tumor; and then\n
(ii) contacting the irradiated tumor having stabilized HIF-1 with a composition comprising a minimally therapeutic dose of an inhibitor of inducible nitric oxide synthase to inhibit HIF-1 stabilization, whereby the minimally therapeutic dose of an inhibitor of inducible nitric oxide synthase is sufficient to prevent production of nitric oxide through inducible nitric oxide synthase in tumor-associated macrophages for a number of days following irradiation,\n
whereby a macrophage-mediated stabilization of HIF-1 in the tumor is inhibited such that the radiation therapy is enhanced."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the subject is a mammal."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, wherein the mammal is a human."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the composition inhibits nitrosylation of Cys520 of SEQ ID NO: 6."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the nitric oxide produced by inducible nitric oxide synthase nitrosylates Cys520 of SEQ ID NO: 6, whereby the nitrosylation of Cys520 of SEQ ID NO: 6 stabilizes HIF-1 in the tumor."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the tumor is irradiated in step (i), and then after a period of time the tumor is contacted with the composition in step (ii)."],"number":6,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}