Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R<SUP>2</SUP>, R<SUP>3 </SUP>and R<SUP>4 </SUP>are as defined in the specification) pharmaceutical compositions containing effective amounts of said compounds or their salts are useful as a single agent or in combination with an anti-neoplastic agent or therapeutic radiation having an anti-neoplastic effect for treating diseases or conditions such as cancers.

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