EP 1975231 A1 - Compositions And Methods For The Detection, Diagnosis And Therapy Of Hematological Malignancies - The Lens

Compositions And Methods For The Detection, Diagnosis And Therapy Of Hematological Malignancies

Published: Oct 1, 2008
Earliest Priority: Jan 22 2002
Family: 31
Cited Works: 379
Cited by: 0
Cites: 148
Sequences: 124
Additional Info: Cited Works Published Sequence

Data obtained from: EMBL-EBI Pat NCBI GenBank (EBI) EPO Sequence Listings DDBJ Pat

124 sequences found in this patent (in total)

Download sequences in fasta format: 42 peptides 82 DNAs

Displaying 1 - 10 of 124 sequences

SEQ ID NO

Length

Sequence Type

Locations

Declared organism

Determined organism

Occurrence

Tools

SEQ ID NO

Length

2,672

Sequence Type

DNA

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

205 times in PatSeqDB

in 21 extended families
(5 referenced in claims)
in 27 simple families
(6 referenced in claims)
in 190 documents

Tools

SEQ ID NO

Length

335

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Homo sapiens
Homo sapiens
Public DB hit
GI:19923572
NP_067004
1 of 8 hits reported for Homo sapiens.

Hit length
335 aa

E Value
0E0

BLAST Score
696 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
NP_067004

100% cov

Alignment Length
335 aa

CIGAR string
335M mismatches: 0 - insertions: 0 - deletions: 0
Pan troglodytes
Pan troglodytes
Public DB hit
GI:114560688
XP_001172275
1 of 2 hits reported for Pan troglodytes.

Hit length
335 aa

E Value
0E0

BLAST Score
685.6 bits

Similarity

99.1%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
XP_001172275

100% cov

Alignment Length
335 aa
Pongo abelii
Pongo abelii
Public DB hit
GI:297662975
XP_002809957
1 of 2 hits reported for Pongo abelii.

Hit length
335 aa

E Value
1.61E-176

BLAST Score
623.6 bits

Similarity

97.31%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
XP_002809957

100% cov

Alignment Length
335 aa
Macaca mulatta
Macaca mulatta
Public DB hit
GI:109017687
XP_001117618

Hit length
335 aa

E Value
7.11E-156

BLAST Score
555.1 bits

Similarity

92.54%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
XP_001117618

100% cov

Alignment Length
335 aa
Callithrix jacchus
Callithrix jacchus
Public DB hit
GI:296229396
XP_002760223

Hit length
335 aa

E Value
8.94E-144

BLAST Score
515 bits

Similarity

87.76%

Coverage

100%

Alignment (schematic)

SEQ ID NO 2

100% cov
XP_002760223

100% cov

Alignment Length
335 aa
Nomascus leucogenys
Nomascus leucogenys
Public DB hit
GI:332219244
XP_003258766

Hit length
228 aa

E Value
9.92E-100

BLAST Score
368.6 bits

Similarity

94.93%

Coverage

64.48%

Alignment (schematic)

SEQ ID NO 2

64.48% cov
XP_003258766

95.18% cov

Alignment Length
217 aa

Occurrence

1350 times in PatSeqDB

in 64 extended families
(23 referenced in claims)
in 186 simple families
(81 referenced in claims)
in 1322 documents

Tools

SEQ ID NO

Length

834

Sequence Type

DNA

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Homo sapiens
Homo sapiens
Public DB hit
GI:29407
Z14954
1 of 8 hits reported for Homo sapiens.

Hit length
834 bp

E Value
0E0

BLAST Score
1,541.2 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 3

100% cov
Z14954

100% cov

Alignment Length
834 bp

CIGAR string
834M mismatches: 0 - insertions: 0 - deletions: 0
Pan troglodytes
Pan troglodytes
Public DB hit
GI:332845304
XM_523298

Hit length
996 bp

E Value
0E0

BLAST Score
1,508 bits

Similarity

99.28%

Coverage

100%

Alignment (schematic)

SEQ ID NO 3

100% cov
XM_523298

83.73% cov

Alignment Length
835 bp
Nomascus leucogenys
Nomascus leucogenys
Public DB hit
GI:332240337
XM_003269297

Hit length
994 bp

E Value
0E0

BLAST Score
1,391.6 bits

Similarity

96.77%

Coverage

100%

Alignment (schematic)

SEQ ID NO 3

100% cov
XM_003269297

83.9% cov

Alignment Length
837 bp
Pongo abelii
Pongo abelii
Public DB hit
GI:297698135
XM_002826139

Hit length
678 bp

E Value
0E0

BLAST Score
1,077.7 bits

Similarity

97.18%

Coverage

76.5%

Alignment (schematic)

SEQ ID NO 3

76.5% cov
XM_002826139

93.95% cov

Alignment Length
638 bp
synthetic construct
synthetic construct
Public DB hit
GI:61355145
AY888160
1 of 3 hits reported for synthetic construct.

Hit length
555 bp

E Value
0E0

BLAST Score
1,026 bits

Similarity

100%

Coverage

66.55%

Alignment (schematic)

SEQ ID NO 3

66.55% cov
AY888160

100% cov

Alignment Length
555 bp
Macaca mulatta
Macaca mulatta
Public DB hit
GI:297283516
XM_001106892

Hit length
552 bp

E Value
0E0

BLAST Score
867.2 bits

Similarity

94.95%

Coverage

66.55%

Alignment (schematic)

SEQ ID NO 3

66.55% cov
XM_001106892

100% cov

Alignment Length
555 bp

Occurrence

35 times in PatSeqDB

in 5 extended families
(2 referenced in claims)
in 6 simple families
(2 referenced in claims)
in 34 documents

Tools

SEQ ID NO

Length

184

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Pan troglodytes
Pan troglodytes
Public DB hit
GI:114661063
XP_523298
1 of 2 hits reported for Pan troglodytes.

Hit length
184 aa

E Value
2.61E-103

BLAST Score
378.6 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 4

100% cov
XP_523298

100% cov

Alignment Length
184 aa

CIGAR string
184M mismatches: 0 - insertions: 0 - deletions: 0
Homo sapiens
Homo sapiens
Public DB hit
GI:33807
CAA78680
1 of 3 hits reported for Homo sapiens.

Hit length
288 aa

E Value
2.61E-103

BLAST Score
378.6 bits

Similarity

100%

Coverage

99.46%

Alignment (schematic)

SEQ ID NO 4

99.46% cov
CAA78680

63.54% cov

Alignment Length
183 aa

CIGAR string
1HMN181M mismatches: 1 - insertions: 0 - deletions: 0
Nomascus leucogenys
Nomascus leucogenys
Public DB hit
GI:332240338
XP_003269345

Hit length
183 aa

E Value
6.76E-99

BLAST Score
364 bits

Similarity

97.8%

Coverage

98.91%

Alignment (schematic)

SEQ ID NO 4

98.91% cov
XP_003269345

99.45% cov

Alignment Length
182 aa
Macaca mulatta
Macaca mulatta
Public DB hit
GI:109127645
XP_001106892

Hit length
183 aa

E Value
1.41E-93

BLAST Score
346.3 bits

Similarity

94.57%

Coverage

100%

Alignment (schematic)

SEQ ID NO 4

100% cov
XP_001106892

100% cov

Alignment Length
184 aa
Callithrix jacchus
Callithrix jacchus
Public DB hit
GI:296219617
XP_002755963

Hit length
183 aa

E Value
9.07E-92

BLAST Score
340.5 bits

Similarity

94.57%

Coverage

100%

Alignment (schematic)

SEQ ID NO 4

100% cov
XP_002755963

100% cov

Alignment Length
184 aa
Oryctolagus cuniculus
Oryctolagus cuniculus
Public DB hit
GI:291390617
XP_002711843

Hit length
240 aa

E Value
1.17E-67

BLAST Score
260.4 bits

Similarity

80.68%

Coverage

93.48%

Alignment (schematic)

SEQ ID NO 4

93.48% cov
XP_002711843

72.92% cov

Alignment Length
176 aa
Ailuropoda melanoleuca
Ailuropoda melanoleuca
Public DB hit
GI:281339208
EFB14792
1 of 2 hits reported for Ailuropoda melanoleuca.

Hit length
176 aa

E Value
6.33E-64

BLAST Score
248.1 bits

Similarity

78.38%

Coverage

98.91%

Alignment (schematic)

SEQ ID NO 4

98.91% cov
EFB14792

100% cov

Alignment Length
185 aa
Sus scrofa
Sus scrofa
Public DB hit
GI:311251487
XP_003124635

Hit length
178 aa

E Value
1.68E-59

BLAST Score
233 bits

Similarity

77.17%

Coverage

98.37%

Alignment (schematic)

SEQ ID NO 4

98.37% cov
XP_003124635

100% cov

Alignment Length
184 aa

Occurrence

399 times in PatSeqDB

in 57 extended families
(17 referenced in claims)
in 67 simple families
(19 referenced in claims)
in 346 documents

Tools

SEQ ID NO

Length

1,339

Sequence Type

DNA

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Homo sapiens
Homo sapiens
Public DB hit
GI:3169292
AF057557
1 of 10 hits reported for Homo sapiens.

Hit length
1,339 bp

E Value
0E0

BLAST Score
2,473.8 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 5

100% cov
AF057557

100% cov

Alignment Length
1,339 bp

CIGAR string
1339M mismatches: 0 - insertions: 0 - deletions: 0
Pan troglodytes
Pan troglodytes
Public DB hit
GI:332811744
XM_001165443

Hit length
3,319 bp

E Value
0E0

BLAST Score
2,420.2 bits

Similarity

99.25%

Coverage

100%

Alignment (schematic)

SEQ ID NO 5

100% cov
XM_001165443

40.4% cov

Alignment Length
1,341 bp

CIGAR string
266MN36MN191MN347MN164MN5MN11MN2MN270MI19MI20M mismatches: 8 - insertions: 2 - deletions: 0
Nomascus leucogenys
Nomascus leucogenys
Public DB hit
GI:332247732
XM_003272968
1 of 2 hits reported for Nomascus leucogenys.

Hit length
3,186 bp

E Value
0E0

BLAST Score
2,183.9 bits

Similarity

96.13%

Coverage

100%

Alignment (schematic)

SEQ ID NO 5

100% cov
XM_003272968

42% cov

Alignment Length
1,342 bp

CIGAR string
15MN39MN4MN87MN18M2DMD21MN5MN47MN12M2N5MN36MN20MN5MN5MN27MN59MN2MN50MN47M2N15MN79MN16MN92MN23MN26MN22MN32MN2MN2MN2MN62MN94MD5MN2MI10MN3MN91MN18MN3MN59MN18MN13MN2MN9MN34MN5MN7MI19MI20M mismatches: 45 - insertions: 3 - deletions: 4
Pongo abelii
Pongo abelii
Public DB hit
GI:297662153
XM_002809552
1 of 2 hits reported for Pongo abelii.

Hit length
1,577 bp

E Value
0E0

BLAST Score
2,183.9 bits

Similarity

97.36%

Coverage

95.82%

Alignment (schematic)

SEQ ID NO 5

95.82% cov
XM_002809552

81.48% cov

Alignment Length
1,286 bp

CIGAR string
56H52MN70MN66MN19MN36MN20MN5MN23MN171M2N15MN3MN62MN12MN54MN10MN43MN109MN92MN71MN5MN11MN85MN28MN63MNMN16MI2MD7MN16MN43MN4MI17MNMI20M mismatches: 30 - insertions: 3 - deletions: 1
synthetic construct
synthetic construct
Public DB hit
GI:123979591
DQ890699
1 of 6 hits reported for synthetic construct.

Hit length
1,213 bp

E Value
0E0

BLAST Score
2,158 bits

Similarity

99.91%

Coverage

87.45%

Alignment (schematic)

SEQ ID NO 5

87.45% cov
DQ890699

96.54% cov

Alignment Length
1,171 bp

CIGAR string
19H995MN175M149H mismatches: 1 - insertions: 0 - deletions: 0
Macaca mulatta
Macaca mulatta
Public DB hit
GI:297280922
XM_001084243

Hit length
1,897 bp

E Value
0E0

BLAST Score
2,098.9 bits

Similarity

94.94%

Coverage

100%

Alignment (schematic)

SEQ ID NO 5

100% cov
XM_001084243

70.69% cov

Alignment Length
1,343 bp

CIGAR string
15MN9MN11MN22MN38MN56MN19MN2MN18MN8MN19M2N17MN56MN26MN10MN10MN4MN114MN20MN32M2N6MN8MN34MN29MN7MN6MN30MN15M2N12MNMN3MI3MD36MN2MN15MN30MN6MN52MN2MN49MN8M2N18MNMN65MN16MD4MI2MN11MN54MN21MN12MN5MN22MN13MN45MN6MN11MN26MN9MN4MN19MN13MI16MN2MI20M mismatches: 62 - insertions: 4 - deletions: 2

Occurrence

18 times in PatSeqDB

in 4 families
(2 referenced in claims)
in 18 documents

Tools

SEQ ID NO

Length

390

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Homo sapiens
Homo sapiens
Public DB hit
GI:4885641
NP_005440
1 of 4 hits reported for Homo sapiens.

Hit length
390 aa

E Value
0E0

BLAST Score
803.1 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
NP_005440

100% cov

Alignment Length
390 aa

CIGAR string
390M mismatches: 0 - insertions: 0 - deletions: 0
synthetic construct
synthetic construct
Public DB hit
GI:30584491
AAP36498

Hit length
391 aa

E Value
0E0

BLAST Score
803.1 bits

Similarity

100%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
AAP36498

99.74% cov

Alignment Length
390 aa

CIGAR string
390M mismatches: 0 - insertions: 0 - deletions: 0
Pan troglodytes
Pan troglodytes
Public DB hit
GI:114572242
XP_001165443
1 of 2 hits reported for Pan troglodytes.

Hit length
390 aa

E Value
0E0

BLAST Score
801.2 bits

Similarity

99.74%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
XP_001165443

100% cov

Alignment Length
390 aa

CIGAR string
82MN307M mismatches: 1 - insertions: 0 - deletions: 0
Nomascus leucogenys
Nomascus leucogenys
Public DB hit
GI:332247733
XP_003273016
1 of 3 hits reported for Nomascus leucogenys.

Hit length
389 aa

E Value
0E0

BLAST Score
740 bits

Similarity

97.18%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
XP_003273016

100% cov

Alignment Length
390 aa
Pongo abelii
Pongo abelii
Public DB hit
GI:297662154
XP_002809598

Hit length
377 aa

E Value
0E0

BLAST Score
696.8 bits

Similarity

97.88%

Coverage

96.67%

Alignment (schematic)

SEQ ID NO 6

96.67% cov
XP_002809598

100% cov

Alignment Length
377 aa
Macaca mulatta
Macaca mulatta
Public DB hit
GI:109018574
XP_001084243

Hit length
390 aa

E Value
0E0

BLAST Score
686.8 bits

Similarity

94.1%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
XP_001084243

100% cov

Alignment Length
390 aa
Callithrix jacchus
Callithrix jacchus
Public DB hit
GI:296230615
XP_002760782

Hit length
389 aa

E Value
4.29E-175

BLAST Score
619.4 bits

Similarity

86.92%

Coverage

100%

Alignment (schematic)

SEQ ID NO 6

100% cov
XP_002760782

100% cov

Alignment Length
390 aa

Occurrence

189 times in PatSeqDB

in 31 extended families
(12 referenced in claims)
in 33 simple families
(13 referenced in claims)
in 143 documents

Tools

SEQ ID NO

Length

2,007

Sequence Type

DNA

Locations

Undetermined

Declared organism

Artificial

Determined organism

Occurrence

14 times in PatSeqDB

in 2 families
in 14 documents

Tools

SEQ ID NO

Length

669

Sequence Type

peptide

Locations

Undetermined

Declared organism

Artificial

Determined organism

Occurrence

14 times in PatSeqDB

in 2 families
in 14 documents

Tools

SEQ ID NO

Length

3,604

Sequence Type

DNA

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

10 times in PatSeqDB

in 10 documents

Tools

SEQ ID NO

Length

662

Sequence Type

peptide

Locations

Undetermined

Declared organism

Homo sapiens

Determined organism

Occurrence

48 times in PatSeqDB

in 6 extended families
(2 referenced in claims)
in 7 simple families
(3 referenced in claims)
in 33 documents

Tools

124 sequences found in this patent (in total)

Filter sequences

Displaying 1 - 10 of 124 sequences

Homo sapiens

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

CIGAR string

Pan troglodytes

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

CIGAR string

Pongo abelii

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

CIGAR string

Homo sapiens

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

CIGAR string

Pan troglodytes

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Pongo abelii

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Macaca mulatta

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Callithrix jacchus

Public DB hit

Hit length

E Value

BLAST Score

Similarity

Coverage

Alignment (schematic)

Alignment Length

Nomascus leucogenys