Remedy For Angiogenesis-related Disease Comprising Chondromodulin-i As The Active Ingredient

  • Published: Jul 23, 2008
  • Earliest Priority: Sep 22 2005
  • Family: 5
  • Cited Works: 0
  • Cited by: 0
  • Cites: 0
  • Sequences: 11
  • Additional Info: Published Sequence
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Abstract

An objective of the present invention is to analyze the function of anti-angiogenic factors in cardiac valves or such to elucidate the developmental mechanism of angiogenesis-induced diseases. A more specific objective is to provide therapeutic agents for angiogenesis-induced diseases such as valvular heart disease, and methods of efficiently screening for the therapeutic agents. The present inventors discovered that chondromodulin-I was markedly expressed in cardiac valves, and plays an important role in maintaining normal functions of the valves by preventing angiogenesis, thickening, and calcification which lead to valvular heart diseases. Chondromodulin-I proteins and substances that activate the expression or function of the proteins are expected to have therapeutic effects against angiogenesis-induced diseases.


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Document History
  • Publication: Jul 23, 2008
  • Application: Sep 15, 2006
    EP EP 06810198 A
  • Priority: Sep 15, 2006
    JP 2006318406 W
  • Priority: Sep 22, 2005
    JP 2005275479 A

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