Toxoid Peptides Derived From Phenol Soluble Modulin, Delta Toxin, Superantigens, And Fusions Thereof

Abstract

The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the disclosure provides delta toxin and phenol-soluble modulin peptides as well as mutants, fragments, variants or derivatives thereof. The disclosure further provides multivalent oligopeptides, fusion proteins comprising two or more staphylococcal proteins, e.g., DT, PSM, alpha hemolysin, leukocidin, superantigen, or any fragments, variants, derivatives, or mutants thereof fused together as a single polypeptide in any order.


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Document History
  • Publication: Jan 8, 2019
  • Application: Nov 13, 2017
    US US 201715810419 A
  • Priority: Nov 13, 2017
    US US 201715810419 A
  • Priority: Dec 18, 2015
    US US 201514899993 A
  • Priority: Jun 18, 2014
    US US 2014/0042999 W
  • Priority: Jun 19, 2013
    US US 201361836959 P

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