{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"064-687-362-211-506","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"064-687-362-211-506"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8904,"type":"PATENT","title":"Univ Washington Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15386,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8219,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Total patent: 10892
Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
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administering to the subject a therapeutically effective amount of an antibody or a functional fragment thereof comprising:\n
a heavy chain variable region comprising a heavy chain complementarity determining region (HCDR) 1, a HCDR2, and a HCDR3, comprising amino acids 26-33, 51-58, and 97-110, of SEQ ID NO: 1, respectively; and\n
a light chain variable region comprising a light chain complementarity determining region (LCDR) 1, a LCDR2, and a LCDR3, comprising amino acids 27-30, 48-50, and 87-91, of SEQ ID NO: 2, respectively; and\n
wherein the antibody or the functional fragment specifically binds to gp120, thereby treating the HIV-1 infection in the subject or inhibiting infection of the subject with HIV-1."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the heavy chain variable region comprises the amino acid sequence set forth as SEQ ID NO: 1."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the light chain variable region comprises the amino acid sequence set forth as SEQ ID NO: 2."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein:\n
the heavy chain variable region comprises the HCDR1, the HCDR2, and the HCDR3, and an amino acid sequence at least 90% identical to the amino acid sequence set forth as SEQ ID NO: 1; and\n
the light chain variable region comprises the LCDR1, the LCDR2, and the LCDR3, and an amino acid sequence at least 90% identical to the amino acid sequence set forth as SEQ ID NO: 2."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the heavy chain variable region comprises the amino acid sequence set forth as SEQ ID NO: 1, and the light chain variable region comprises the amino acid sequence set forth as SEQ ID NO: 2."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the antibody is an IgG, an IgM, or an IgA."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the antibody is an IgG1."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the fragment is a Fab fragment, a Fab′ fragment, a F(ab)′2 fragment, a single chain Fv protein (scFv), or a disulfide stabilized Fv protein (dsFv)."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein the fragment is a Fab fragment."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the method comprises treating the HIV-1 infection and the subject is infected with HIV-1."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the method comprises treating the HIV-1 infection and the subject has acquired immune deficiency syndrome (AIDS)."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the method comprises inhibiting infection of the subject with HIV-1 and the subject is at risk of infection with HIV-1."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the subject is pregnant."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the subject is a breastfeeding mother."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the subject is an infant."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the administration is an intravenous administration or a subcutaneous administration."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, further comprising administering to the subject an anti-viral agent."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["A method for treating a human immunodeficiency virus (HIV)-1 infection in a subject or inhibiting infection of a subject with HIV-1, comprising:\n
administering to the subject a therapeutically effective amount of an expression vector comprising a nucleic acid molecule encoding an antibody or a functional fragment thereof comprising:\n
a heavy chain variable region comprising a heavy chain complementarity determining region (HCDR) 1, a HCDR2, and a HCDR3, comprising amino acids 26-33, 51-58, and 97-110, of SEQ ID NO: 1, respectively; and\n
a light chain variable region comprising a light chain complementarity determining region (LCDR) 1, a LCDR2, and a LCDR3, comprising amino acids 27-30, 48-50, and 87-91, of SEQ ID NO: 2, respectively; and\n
wherein the antibody or the functional fragment specifically binds to gp120, and wherein expression of the antibody or antigen binding fragment in the subject treats the HIV-1 infection in the subject or inhibiting infection of the subject with HIV-1."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18, wherein the heavy chain variable region comprises the amino acid sequence set forth as SEQ ID NO: 1, and the light chain variable region comprises the amino acid sequence set forth as SEQ ID NO: 2."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the heavy chain variable region comprises the HCDR1, the HCDR2, and the HCDR3, and an amino acid sequence at least 90% identical to SEQ ID NO: 1."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the light chain variable region comprises an amino acid sequence at least 90% identical to SEQ ID NO: 2."],"number":21,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}