Anti-invasive And Anti-angiogenic Compositions

Abstract

A peptide compound having the sequence Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu [SEQ ID NO:2] or a substitution variant, addition variant or other chemical derivative thereof inhibits cell invasion, endothelial tube formation or angiogenesis in vitro. A number of substitution variants and addition variants of this peptide, preferably capped at the N- and C-termini, as well as peptidomimetic derivates, are useful for treating diseases and conditions mediated by undesired and uncontrolled cell invasion and/or angiogenesis. Pharmaceutical compositions comprising the above peptides and derivatives are administered to subjects in need of such treatment in a dosage sufficient to inhibit invasion and/or angiogenesis. The disclosed compositions and methods are particularly useful for suppressing the growth and metastasis of tumors.


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Document History
  • Publication: Feb 7, 2012
  • Application: Aug 30, 2010
    US US 87186810 A
  • Priority: Aug 30, 2010
    US US 87186810 A
  • Priority: Nov 15, 2006
    US US 60030206 A
  • Priority: Sep 6, 2002
    US US 23555202 A
  • Priority: Nov 10, 1999
    US US 43713699 A
  • Priority: Jul 25, 1997
    US US 90032797 A

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