Highly Simplified Lateral Flow-based Nucleic Acid Sample Preparation And Passive Fluid Flow Control

Abstract

Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays.


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Document History
  • Publication: Dec 8, 2015
  • Application: Nov 5, 2010
    US US 94097310 A
  • Priority: Nov 5, 2010
    US US 94097310 A
  • Priority: May 5, 2009
    US US 2009/0002809 W
  • Priority: May 5, 2008
    US US 12664508 P

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