Gene Polymorphisms As Predictors Of Tumor Progression And Their Use In Cancer Therapy


The invention provides compositions and methods for determining the likelihood of successful treatment with a pyrimidine based antimetabolite chemotherapy drug and a platinum based chemotherapy drug, such as 5-FU/oxaliplatin. The methods comprise determining the genomic polymorphism present in a predetermined region of a gene of interest and correlating the polymorphism to the predictive response. Patients identified as responsive are then treated with the appropriate therapy.

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Document History
  • Publication: Jul 24, 2008
  • Application: Jan 17, 2008
    WO US 2008/0000651 W
  • Priority: Jan 18, 2007
    US US 88561007 P

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