Alternate Morpheein Forms Of Allosteric Proteins As A Target For The Development Of Bioactive Molecules

  • Published: Feb 19, 2009
  • Earliest Priority: Jul 07 2003
  • Family: 2
  • Cited Works: 0
  • Cited by: 7
  • Cites: 14
  • Sequences: 153
  • Additional Info: Full text Sequence

A composition having an agent adapted to affect a multimeric protein by binding to a binding site of the multimeric protein and thereby affecting an equilibrium of units, wherein the multimeric protein has an assembly having a plurality of said units, wherein each of the units has a first complementary surface and a second complementary surface and wherein the first complementary surface of one unit is associated with the second complementary surface of another unit, provided that the assembly is at least one of different quaternary isoforms on a condition that in the multimeric protein (1) a structure of each of the units determines a structure of the different quaternary isoforms, (2) the units are in the equilibrium and (3) the structure of the different quaternary isoforms influences a function of the multimeric protein.

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Document History
  • Publication: Feb 19, 2009
  • Application: Jun 19, 2008
    US US 14243508 A
  • Priority: Jun 19, 2008
    US US 14243508 A
  • Priority: Jan 6, 2006
    US US 32776206 A
  • Priority: Jun 15, 2005
    US US 69064905 P
  • Priority: Jul 7, 2004
    US US 2004/0021722 W
  • Priority: Jun 4, 2004
    US US 57731204 P
  • Priority: Jul 7, 2003
    US US 48525303 P

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