Nucleic Acids Encoding Mutations In Sodium Channels Related To Epilepsy

Abstract

An isolated nucleic acid molecule encoding a mutant alpha subunit of a mammalian voltage-gated sodium channel, wherein a mutation event selected from the group consisting of point mutations, deletions, insertions and rearrangements has occurred and said mutation event disrupts the functioning of an assembled sodium channel comprising this mutated subunit so as to produce an epilepsy phenotype, with the proviso that the mutation event is not a C2624T transition or a G4943A transition.


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Document History
  • Publication: May 4, 2010
  • Application: Oct 31, 2005
    US US 26264705 A
  • Priority: Oct 31, 2005
    US US 26264705 A
  • Priority: Oct 12, 2004
    US US 48283404 A
  • Priority: Aug 6, 2004
    AU AU 2004/001051 W
  • Priority: Oct 8, 2003
    US US 45112603 A
  • Priority: Aug 7, 2003
    AU AU 2003/904154 A
  • Priority: Jul 8, 2002
    AU AU 1910/002009 W
  • Priority: May 13, 2002
    AU AU PS229202 A
  • Priority: Mar 5, 2002
    AU AU PS091002 A
  • Priority: Dec 20, 2001
    AU AU 1948/001016 W
  • Priority: Jul 18, 2001
    AU AU PR645201 A

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