Antiviral Activity Of Cyclopentene Nitro-ester And Derivatives


Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (>99% ee) was influenced by desymmetrization catalyzed by Pseudomonas cepacia lipase and the stereo selective nature of the palladium catalyzed transformations.

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Document History
  • Publication: Nov 27, 2012
  • Application: Jun 9, 2010
    US US 79729010 A
  • Priority: Jun 9, 2010
    US US 79729010 A
  • Priority: Dec 10, 2008
    US US 2008/0086155 W
  • Priority: Dec 10, 2007
    US US 1261107 P

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