Pyridinoylpiperidines As 5-ht1f Agonists


The present invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen, halo, or C1-C3 alkyl; R5 is hydrogen or C1-C3 alkyl; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HTlF receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.

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Document History
  • Publication: Jun 10, 2014
  • Application: Feb 1, 2012
    US US 201213363895 A
  • Priority: Feb 1, 2012
    US US 201213363895 A
  • Priority: Aug 7, 2008
    US US 22191908 A
  • Priority: Sep 28, 2004
    US US 50977004 A
  • Priority: Mar 27, 2003
    US US 0308455 W
  • Priority: Mar 29, 2002
    US US 36908802 P

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