{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"059-858-220-051-706","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"059-858-220-051-706","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10787,"type":"PATENT","title":"Rutgers University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7108,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8257,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Rutgers Univ*\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4935
Search Applicants and Owners separately: univ* AND bonn
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 505
Search Applicants and Owners separately: \"Rutgers Univ*\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4935
Search Applicants and Owners separately: univ* AND bonn
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or a pharmaceutically acceptable salt thereof,\n
wherein:\n
Ring A is selected from the group consisting of:\n\n
Ring B is selected from the group consisting of:\n\n
each X1 and X2 is independently —CH— or —N—;\n
X3 is —NH—;\n
Xa and Xb are independently —O— or —S—;\n
Xa1 and Xb1 are —CH—;\n
Xc and Xd are independently oxygen optionally substituted with cyanoethyl, or sulfur;\n
each Xe and Xf is —O—;\n
each W is independently P;\n
each R1 and R2 is independently selected from the group consisting of hydrogen, halogen, —NH2 and —ORa, wherein Ra is an oxygen protecting group, hydrogen, or C1-6 alkyl;\n
each R3, R5, and R7 is independently selected from the group consisting of hydrogen, halogen, —NH2, —OR wherein R is hydrogen or C1-6 alkyl, —SR wherein R is hydrogen or C1-6 alkyl, and —NHC(O)R wherein R is hydrogen, C1-6 alkyl, or phenyl;\n
each R4 is independently selected from the group consisting of hydrogen, halogen, —NH2, —OR wherein R is C1-6 alkyl, —SR wherein R is hydrogen or C1-6 alkyl, and —NHC(O)R wherein R is hydrogen, C1-6 alkyl, or phenyl;\n
each R6 is independently selected from the group consisting of halogen, —NH2, —OR wherein R is hydrogen or C1-6 alkyl, —SR wherein R is hydrogen or C1-6 alkyl, and —NHC(O)R wherein R is hydrogen, C1-6 alkyl, or phenyl;\n
each R10 and R11 is independently hydrogen or C1-2 alkyl; and\n
the subindex of the carbon atoms to which each R8 and R9 is attached is 0;\n
with the proviso that the compound is other than:"],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein Ring A is"],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein Ring B is"],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein Ring B is"],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein R1 is selected from the group consisting of hydrogen, halogen, and —OH."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 5, wherein R2 is selected from the group consisting of hydrogen, halogen, and —OH."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound is of formula II-a:\n
or a pharmaceutically acceptable salt thereof."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound is of formula X, XII, XIII, XIV, XV, or XVI:\n\n
or a pharmaceutically acceptable salt thereof."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["A compound:\n
or a pharmaceutically acceptable salt thereof."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 9, wherein the compound is:\n
or a pharmaceutically acceptable salt thereof."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 10, in isolated form."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 11, in purified form."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 7, wherein\n
Ring A is\n\n
each X1 is N;\n
R3 and R5 are hydrogen;\n
R4 is NH2;\n
Xa and Xb are O;\n
R1 and R2 are OH; and\n
R10 and R11 are hydrogen;\nor a pharmaceutically acceptable salt thereof."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 14, wherein one or both of Xc and Xd is sulfur."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 14, wherein both of Xc and Xd are oxygen."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 14, wherein both of Xc and Xd are sulfur."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 7, wherein\n
Ring A is\n\n
each X1 is N;\n
R3 and R5 are hydrogen;\n
R4 is NH2;\n
Xa and Xb are O;\n
Xc and Xd, are independently oxygen or sulfur;\n
R1 and R2 are OH; and\n
R10 and R11 are hydrogen;\nor a pharmaceutically acceptable salt thereof."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each X1 is —N—."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each X2 is —N—."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein Xa is —O—."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein Xb is —O—."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein Xc and Xd are both oxygen."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein Xc and Xd are both sulfur."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 5, wherein R1 is —OH."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 6, wherein R2 is —OH."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each R3, R5, and R7 is independently selected from the group consisting of hydrogen and halogen."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 27, wherein each of R3, R5, and R7 is hydrogen."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each of R4 is independently selected from the group consisting of hydrogen, halogen, and —NH2, and each of R6 is independently selected from the group consisting of halogen and —NH2."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 29, wherein R4 and R6 are each —NH2."],"number":30,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein R10 and R11 are hydrogen."],"number":31,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each R3, R5, and R7 is independently selected from the group consisting of hydrogen, halogen, —NH2, —OR wherein R is hydrogen, —SR wherein R is hydrogen, and —NHC(O)R wherein R is hydrogen;\n
each R4 is independently selected from the group consisting of hydrogen, halogen, —NH2, —SR wherein R is hydrogen, and —NHC(O)R wherein R is hydrogen;\n
each R6 is independently selected from the group consisting of halogen, —NH2, —OR wherein R is hydrogen, —SR wherein R is hydrogen, and —NHC(O)R wherein R is hydrogen."],"number":32,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising the compound of claim 7 and a pharmaceutically acceptable carrier."],"number":33,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising the compound of claim 17 and a pharmaceutically acceptable carrier."],"number":34,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein Xc and Xd are independently oxygen or sulfur."],"number":35,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each R1 and R2 is independently selected from the group consisting of hydrogen, halogen, —NH2, and —ORa, wherein Ra is hydrogen or C1-6 alkyl."],"number":36,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each R10 and R11 is hydrogen."],"number":37,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein Xc and Xd are independently oxygen or sulfur; and each R1 and R2 is independently selected from the group consisting of hydrogen, halogen, —NH2, and —ORa, wherein Ra is hydrogen or C1-6 alkyl."],"number":38,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein Xc and Xd are independently oxygen or sulfur; and each R10 and R11 is hydrogen."],"number":39,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each R1 and R2 is independently selected from the group consisting of hydrogen, halogen, —NH2, and —ORa, wherein Ra is hydrogen or C1-6 alkyl; and each R10 and R11 is hydrogen."],"number":40,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein Xc and Xd are independently oxygen or sulfur; each Rl and R2 is independently selected from the group consisting of hydrogen, halogen, —NH2, and —ORa, wherein Ra is hydrogen or C1-6 alkyl; and each R10 and R11 is hydrogen."],"number":41,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound is of formula XIV\nwherein:\n
R3 and R5 are independently hydrogen or halogen;\n
R4 is selected from the group consisting of hydrogen, halogen, and —NH2;\n
R6 is selected from the group consisting of halogen and —NH2;\n
Xc and Xd are independently O or S;\n
R1 is selected from the group consisting of hydrogen, halogen, —ORa, and —NH2, wherein Ra is hydrogen or C1-6 alkyl; and\n
R2 is selected from the group consisting of hydrogen, halogen, —ORa, and —NH2, wherein Ra is hydrogen or C1-6 alkyl."],"number":42,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound is of formula XVI\nwherein:\n
R3 and R5 are independently hydrogen or halogen;\n
R4 is selected from the group consisting of hydrogen, halogen, and —NH2;\n
Xc and Xd are independently O or S;\n
Rl is selected from the group consisting of hydrogen, halogen, —ORa, and —NH2, wherein Ra is hydrogen or C1-6 alkyl; and\n
R2 is selected from the group consisting of hydrogen, halogen, —ORa, and —NH2, wherein Ra is hydrogen or C1-6 alkyl."],"number":43,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising the compound of claim 12 and a pharmaceutically acceptable carrier."],"number":44,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}